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Pmpcb peptidase (mitochondrial processing) beta [ Mus musculus (house mouse) ]

Gene ID: 73078, updated on 12-May-2024

Summary

Official Symbol
Pmpcbprovided by MGI
Official Full Name
peptidase (mitochondrial processing) betaprovided by MGI
Primary source
MGI:MGI:1920328
See related
Ensembl:ENSMUSG00000029017 AllianceGenome:MGI:1920328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MPPB; MPP11; MPPP52; 3110004O18Rik
Summary
Predicted to enable metalloendopeptidase activity. Predicted to contribute to metallopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrial inner membrane. Is expressed in several structures, including extraembryonic component; gallbladder; genitourinary system; gut gland; and nervous system. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 46.3), heart adult (RPKM 42.1) and 28 other tissues See more
Orthologs
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Genomic context

See Pmpcb in Genome Data Viewer
Location:
5 A3; 5 9.97 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21942158..21962150)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21737160..21757152)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene BCL2-associated transcription factor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6311 Neighboring gene VISTA enhancer mm1463 Neighboring gene STARR-positive B cell enhancer ABC_E11721 Neighboring gene predicted gene, 54323 Neighboring gene STARR-seq mESC enhancer starr_12576 Neighboring gene predicted gene 15715 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 
  • Transgenic (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing involved in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein processing involved in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
part_of mitochondrial processing peptidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial-processing peptidase subunit beta
Names
P-52
beta-MPP
NP_001404726.1
NP_082707.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417797.1NP_001404726.1  mitochondrial-processing peptidase subunit beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125313, AC125343
  2. NM_028431.2NP_082707.1  mitochondrial-processing peptidase subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_082707.1

    Status: VALIDATED

    Source sequence(s)
    AK013995
    Consensus CDS
    CCDS19106.1
    UniProtKB/Swiss-Prot
    Q9CXT8
    UniProtKB/TrEMBL
    Q3TET5
    Related
    ENSMUSP00000030882.6, ENSMUST00000030882.12
    Conserved Domains (1) summary
    COG0612
    Location:46478
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]

RNA

  1. NR_184580.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125313, AC125343

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21942158..21962150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)