U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PPIAL4E peptidylprolyl isomerase A like 4E [ Homo sapiens (human) ]

Gene ID: 730262, updated on 23-Nov-2023

Summary

Official Symbol
PPIAL4Eprovided by HGNC
Official Full Name
peptidylprolyl isomerase A like 4Eprovided by HGNC
Primary source
HGNC:HGNC:33997
See related
Ensembl:ENSG00000271567 MIM:608608; AllianceGenome:HGNC:33997
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COAS2; PPIAL4F
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PPIAL4E in Genome Data Viewer
Location:
1q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (144372875..144373634, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (143692960..143693719)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (148644036..148644795)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene D(1B) dopamine receptor-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:148864647-148865255 Neighboring gene extensin Neighboring gene Sharpr-MPRA regulatory region 1883 duplicate 2 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:148645625-148646126 Neighboring gene hESC enhancers GRCh37_chr1:148603911-148604598 and GRCh37_chr1:148766495-148767201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:148603221-148603910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:148760689-148761190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1257 Neighboring gene tRNA-Asn (anticodon GTT) 3-1 Neighboring gene RNA, variant U1 small nuclear 15

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase A-like 4E
Names
PPIase A-like 4E
PPIase A-like 4F
Peptidyl-prolyl cis-trans isomerase A-like 4F
peptidylprolyl isomerase A (cyclophilin A)-like 4E
NP_001137504.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144032.3NP_001137504.2  peptidyl-prolyl cis-trans isomerase A-like 4E

    See identical proteins and their annotated locations for NP_001137504.2

    Status: INFERRED

    Source sequence(s)
    AC246785
    Consensus CDS
    CCDS76201.1
    UniProtKB/Swiss-Prot
    A0A075B759, P0DN26
    UniProtKB/TrEMBL
    A0A0H2UH34
    Related
    ENSP00000463419.1, ENST00000581164.2
    Conserved Domains (1) summary
    cl00197
    Location:4162
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    144372875..144373634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    143692960..143693719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)