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FAM166B family with sequence similarity 166 member B [ Homo sapiens (human) ]

Gene ID: 730112, updated on 23-Nov-2021

Summary

Official Symbol
FAM166Bprovided by HGNC
Official Full Name
family with sequence similarity 166 member Bprovided by HGNC
Primary source
HGNC:HGNC:34242
See related
Ensembl:ENSG00000215187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in adrenal (RPKM 201.8) and brain (RPKM 11.3) See more
Orthologs
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Genomic context

See FAM166B in Genome Data Viewer
Location:
9p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35561830..35563878, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35561828..35563875, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376026 Neighboring gene RUN and SH3 domain containing 2 Neighboring gene ribosomal protein L36a pseudogene 33 Neighboring gene ribosomal protein S29 pseudogene 17 Neighboring gene microRNA 4667 Neighboring gene testis associated actin remodelling kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC157846

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099951.4NP_001093421.1  protein FAM166B isoform 2

    See identical proteins and their annotated locations for NP_001093421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI383111, BC129999, CB241755
    Consensus CDS
    CCDS47963.1
    UniProtKB/Swiss-Prot
    A8MTA8
    Related
    ENSP00000412746.1, ENST00000447837.1
    Conserved Domains (1) summary
    pfam10629
    Location:1645
    DUF2475; Protein of unknown function (DUF2475)
  2. NM_001164310.3NP_001157782.1  protein FAM166B isoform 1

    See identical proteins and their annotated locations for NP_001157782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AI383111, BC146928, CB241755
    Consensus CDS
    CCDS56572.1
    UniProtKB/Swiss-Prot
    A8MTA8
    Related
    ENSP00000382646.2, ENST00000399742.7
    Conserved Domains (1) summary
    pfam10629
    Location:1672
    DUF2475; Protein of unknown function (DUF2475)
  3. NM_001287238.2NP_001274167.1  protein FAM166B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform 3) has a distinct internal region and is shorter than isoform 1.
    Source sequence(s)
    AI383111, BC171840, CB241755
    UniProtKB/TrEMBL
    B7ZW26
    Conserved Domains (1) summary
    pfam10629
    Location:1672
    DUF2475; Protein of unknown function (DUF2475)
  4. NM_001287239.2NP_001274168.1  protein FAM166B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the coding region, which results in a translational frameshift, compared to variant 1. This resulting protein (isoform 4) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AI383111, BC129999, BC171840, BC171851, CB241755
    UniProtKB/Swiss-Prot
    A8MTA8
    UniProtKB/TrEMBL
    B7ZW26, B7ZW33
    Related
    ENSP00000480923.1, ENST00000619051.4
    Conserved Domains (1) summary
    pfam10629
    Location:1672
    DUF2475; Protein of unknown function (DUF2475)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35561830..35563878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518028.2XP_011516330.1  protein FAM166B isoform X1

    Conserved Domains (1) summary
    pfam10629
    Location:1767
    DUF2475; Protein of unknown function (DUF2475)
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