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MOSMO modulator of smoothened [ Homo sapiens (human) ]

Gene ID: 730094, updated on 23-Nov-2021

Summary

Official Symbol
MOSMOprovided by HGNC
Official Full Name
modulator of smoothenedprovided by HGNC
Primary source
HGNC:HGNC:27087
See related
Ensembl:ENSG00000185716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATTHOG; BC030336; C16orf52
Expression
Ubiquitous expression in adrenal (RPKM 11.6), brain (RPKM 8.9) and 24 other tissues See more
Orthologs
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Genomic context

See MOSMO in Genome Data Viewer
Location:
16p12.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (22008111..22084654)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22019432..22095975)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase core protein 2 Neighboring gene cell division cycle associated 8 pseudogene Neighboring gene PDZ domain containing 9 Neighboring gene islet cell autoantigen 1, 69kDa pseudogene Neighboring gene uncharacterized LOC105371129 Neighboring gene von Willebrand factor A domain containing 3A Neighboring gene short chain dehydrogenase/reductase family 42E, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC26782

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in ciliary membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
modulator of smoothened protein
Names
Attenuator of Hedgehog
uncharacterized protein C16orf52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164579.2NP_001158051.1  modulator of smoothened protein

    See identical proteins and their annotated locations for NP_001158051.1

    Status: VALIDATED

    Source sequence(s)
    AC009019, AC092119
    Consensus CDS
    CCDS58431.1
    UniProtKB/Swiss-Prot
    Q8NHV5
    Related
    ENSP00000454926.1, ENST00000542527.7
    Conserved Domains (1) summary
    pfam18800
    Location:25166
    Atthog; Attenuator of Hedgehog

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    22008111..22084654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    1020384..1096927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173501.1: Suppressed sequence

    Description
    NM_173501.1: This RefSeq was permanently suppressed because currently there is support for the transcript, but not for the protein, and it is a candidate for nonsense-mediated decay.
  2. NR_024104.1: Suppressed sequence

    Description
    NR_024104.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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