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SHISA7 shisa family member 7 [ Homo sapiens (human) ]

Gene ID: 729956, updated on 18-Aug-2020

Summary

Official Symbol
SHISA7provided by HGNC
Official Full Name
shisa family member 7provided by HGNC
Primary source
HGNC:HGNC:35409
See related
Ensembl:ENSG00000187902 MIM:617328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKAMP59
Expression
Biased expression in brain (RPKM 7.7), testis (RPKM 0.8) and 1 other tissue See more
Orthologs

Genomic context

See SHISA7 in Genome Data Viewer
Location:
19q13.42
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55428738..55442863, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55940105..55954230, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L28 Neighboring gene uncharacterized LOC105372462 Neighboring gene small nucleolar RNA, C/D box 157 Neighboring gene Sharpr-MPRA regulatory region 8373 Neighboring gene ubiquitin conjugating enzyme E2 S Neighboring gene isochorismatase domain containing 2 Neighboring gene zinc finger protein 628

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ34341, FLJ37640, FLJ45290, MGC120935, MGC138402, DKFZp547H0214

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ionotropic glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT ionotropic glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
gamma-aminobutyric acid receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
gamma-aminobutyric acid signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of AMPA glutamate receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of AMPA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of GABA-A receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of postsynaptic neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of short-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
asymmetric, glutamatergic, excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT asymmetric, glutamatergic, excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT glutamatergic synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein shisa-7
Names
GABA(A) receptor auxiliary subunit Shisa7
UPF0626 protein A
cystine-knot AMPAR modulating protein of 59 kDa
shisa homolog 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145176.1NP_001138648.1  protein shisa-7 precursor

    See identical proteins and their annotated locations for NP_001138648.1

    Status: VALIDATED

    Source sequence(s)
    AC135592
    Consensus CDS
    CCDS46193.1
    UniProtKB/Swiss-Prot
    A6NL88
    Related
    ENSP00000365503.3, ENST00000376325.8
    Conserved Domains (1) summary
    pfam13908
    Location:80139
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55428738..55442863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175908.3: Suppressed sequence

    Description
    NM_175908.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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