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RGPD2 RANBP2 like and GRIP domain containing 2 [ Homo sapiens (human) ]

Gene ID: 729857, updated on 24-Nov-2020

Summary

Official Symbol
RGPD2provided by HGNC
Official Full Name
RANBP2 like and GRIP domain containing 2provided by HGNC
Primary source
HGNC:HGNC:32415
See related
Ensembl:ENSG00000185304 MIM:612705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP2; NUP358; RANBP2L2
Expression
Broad expression in testis (RPKM 17.3), placenta (RPKM 6.4) and 23 other tissues See more

Genomic context

See RGPD2 in Genome Data Viewer
Location:
2p11.2
Exon count:
32
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (87757198..87992819, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88056717..88125331, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928214 Neighboring gene ANAPC1 pseudogene 4 Neighboring gene plasminogen like B2 Neighboring gene MT-ATP6 pseudogene 28 Neighboring gene MT-ATP8 pseudogene 2 Neighboring gene uncharacterized LOC105374851 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 7 Neighboring gene WBP1 pseudogene 2 Neighboring gene lysine-rich coiled-coil 1 pseudogene Neighboring gene ANAPC1 pseudogene 5 Neighboring gene uncharacterized LOC105374852 Neighboring gene RNA, U2 small nuclear 63, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ56975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RANBP2-like and GRIP domain-containing protein 2
Names
Ran binding protein 2-like 2
nucleoporin
ran-binding protein 2-like 2
ranBP2-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078170.2NP_001071638.2  RANBP2-like and GRIP domain-containing protein 2

    See identical proteins and their annotated locations for NP_001071638.2

    Status: VALIDATED

    Source sequence(s)
    AC093616, AK302429, AY354203
    Consensus CDS
    CCDS42710.2
    UniProtKB/Swiss-Prot
    P0DJD1
    UniProtKB/TrEMBL
    B4DYH0
    Related
    ENSP00000381214.3, ENST00000398146.4
    Conserved Domains (8) summary
    smart00028
    Location:5990
    TPR; Tetratricopeptide repeats
    COG5171
    Location:9681160
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10441160
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13411457
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5888
    TPR; TPR repeat [structural motif]
    pfam01465
    Location:16981740
    GRIP; GRIP domain
    pfam13414
    Location:58125
    TPR_11; TPR repeat
    pfam16704
    Location:16341694
    Rab_bind; Rab binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    87757198..87992819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004845.1XP_016860334.1  RANBP2-like and GRIP domain-containing protein 2 isoform X1

  2. XM_017004847.1XP_016860336.1  RANBP2-like and GRIP domain-containing protein 2 isoform X3

  3. XM_017004846.1XP_016860335.1  RANBP2-like and GRIP domain-containing protein 2 isoform X2

  4. XM_017004850.1XP_016860339.1  RANBP2-like and GRIP domain-containing protein 2 isoform X6

  5. XM_017004849.1XP_016860338.1  RANBP2-like and GRIP domain-containing protein 2 isoform X5

  6. XM_017004848.1XP_016860337.1  RANBP2-like and GRIP domain-containing protein 2 isoform X4

RNA

  1. XR_001738923.2 RNA Sequence

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