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TYMS thymidylate synthetase [ Homo sapiens (human) ]

Gene ID: 7298, updated on 7-Dec-2018

Summary

Official Symbol
TYMSprovided by HGNC
Official Full Name
thymidylate synthetaseprovided by HGNC
Primary source
HGNC:HGNC:12441
See related
Ensembl:ENSG00000176890 MIM:188350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TS; TMS; HST422
Summary
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Expression
Broad expression in bone marrow (RPKM 46.3), testis (RPKM 32.5) and 21 other tissues See more
Orthologs

Genomic context

See TYMS in Genome Data Viewer
Location:
18p11.32
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (657584..673578)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (657590..673499)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 146 Neighboring gene clusterin like 1 Neighboring gene uncharacterized LOC105371952 Neighboring gene TYMS opposite strand Neighboring gene enolase superfamily member 1 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene RNA, U1 small nuclear 109, pseudogene Neighboring gene bolA family member 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88736

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cofactor binding IEA
Inferred from Electronic Annotation
more info
 
folic acid binding IC
Inferred by Curator
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
thymidylate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
thymidylate synthase activity TAS
Traceable Author Statement
more info
PubMed 
translation repressor activity, mRNA regulatory element binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA biosynthetic process IC
Inferred by Curator
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
dTMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dUMP metabolic process IEA
Inferred from Electronic Annotation
more info
 
developmental growth IEA
Inferred from Electronic Annotation
more info
 
immortalization of host cell by virus IEA
Inferred from Electronic Annotation
more info
 
intestinal epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to folic acid IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to organophosphorus IEP
Inferred from Expression Pattern
more info
PubMed 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
tetrahydrofolate interconversion IDA
Inferred from Direct Assay
more info
PubMed 
uracil metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thymidylate synthase
Names
TSase
NP_001062.1
NP_001341796.1
NP_001341797.1
XP_024307010.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028255.1 RefSeqGene

    Range
    5001..20896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_783

mRNA and Protein(s)

  1. NM_001071.4NP_001062.1  thymidylate synthase isoform 1

    See identical proteins and their annotated locations for NP_001062.1

    Status: REVIEWED

    Source sequence(s)
    AK223372, BC018858, BC083512, HY016886, HY269620
    Consensus CDS
    CCDS11821.1
    UniProtKB/Swiss-Prot
    P04818
    UniProtKB/TrEMBL
    Q53Y97
    Related
    ENSP00000315644.10, ENST00000323274.14
    Conserved Domains (1) summary
    pfam00303
    Location:32313
    Thymidylat_synt; Thymidylate synthase
  2. NM_001354867.1NP_001341796.1  thymidylate synthase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB077208, AK223372, BC083512, HY016886, HY269620
    Consensus CDS
    CCDS86658.1
    Related
    ENSP00000314727.7, ENST00000323224.7
    Conserved Domains (1) summary
    cl19097
    Location:27279
    TS_Pyrimidine_HMase; Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the ...
  3. NM_001354868.1NP_001341797.1  thymidylate synthase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB077207, AK223372, BC083512, HY016886, HY269620
    Consensus CDS
    CCDS86659.1
    Related
    ENSP00000314902.5, ENST00000323250.9
    Conserved Domains (1) summary
    pfam00303
    Location:32230
    Thymidylat_synt; Thymidylate synthase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    657584..673578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451242.1XP_024307010.1  thymidylate synthase isoform X1

    Conserved Domains (1) summary
    pfam00303
    Location:26186
    Thymidylat_synt; Thymidylate synthase
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