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TYK2 tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 7297, updated on 28-Nov-2021

Summary

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Official Symbol
TYK2provided by HGNC
Official Full Name
tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:12440
See related
Ensembl:ENSG00000105397 MIM:176941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JTK1; IMD35
Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues See more
Orthologs
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Genomic context

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See TYK2 in Genome Data Viewer
Location:
19p13.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10350528..10380572, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10461209..10491248, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene intercellular adhesion molecule 3 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene microRNA 1181 Neighboring gene phosphodiesterase 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia. Tavakoli Shirazi P, et al. Cancer Lett, 2021 Aug 1. PMID 33971281
  2. TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients. Mori H, et al. Genes (Basel), 2021 Mar 11. PMID 33799705, Free PMC Article
  3. Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years. Kerner G, et al. Am J Hum Genet, 2021 Mar 4. PMID 33667394, Free PMC Article
  4. TYK2 Variants in B-Acute Lymphoblastic Leukaemia. Turrubiartes-Martínez E, et al. Genes (Basel), 2020 Nov 28. PMID 33260630, Free PMC Article
  5. The role of a functional variant of TYK2 in vasculitides and infections. Ortiz-Fernández L, et al. Clin Exp Rheumatol, 2020 Sep-Oct. PMID 32167874

See all (214) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia.
    Title: Constitutive JAK/STAT signaling is the primary mechanism of resistance to JAKi in TYK2-rearranged acute lymphoblastic leukemia.
  2. Association of GTF2I, NFKB1, and TYK2 Regional Polymorphisms With Systemic Sclerosis in a Chinese Han Population.
    Title: Association of GTF2I, NFKB1, and TYK2 Regional Polymorphisms With Systemic Sclerosis in a Chinese Han Population.
  3. TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.
    Title: <i>TYK2</i> Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.
  4. TYK2 Variants in B-Acute Lymphoblastic Leukaemia.
    Title: TYK2 Variants in B-Acute Lymphoblastic Leukaemia.
  5. Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population.
    Title: Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population.
  6. JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma.
    Title: JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma.
  7. Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years.
    Title: Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years.
  8. A New Patient with Inherited TYK2 Deficiency.
    Title: A New Patient with Inherited TYK2 Deficiency.
  9. Whole-Exome Sequencing of Patients With Posterior Segment Uveitis.
    Title: Whole-Exome Sequencing of Patients With Posterior Segment Uveitis.
  10. The role of a functional variant of TYK2 in vasculitides and infections.
    Title: The role of a functional variant of TYK2 in vasculitides and infections.
Submit: New GeneRIF Correction See all GeneRIFs (96)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
GeneReviews: Not available
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
GeneReviews: Not available
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Immunodeficiency 35
MedGen: C1969086 OMIM: 611521 GeneReviews: Not available
Compare labs
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables growth hormone receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables type 1 angiotensin receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NK T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of natural killer cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in type I interferon signaling pathway TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
non-receptor tyrosine-protein kinase TYK2
NP_001372126.1
NP_001372127.1
NP_001372128.1
NP_001372129.1
NP_001372130.1
NP_001372131.1
NP_001372132.1
NP_001372133.1
NP_001372134.1
NP_001372135.1
NP_001372136.1
NP_003322.3
XP_011526547.1
XP_011526548.1
XP_011526549.1
XP_011526551.1
XP_011526553.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007872.1 RefSeqGene

    Range
    5001..35045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_121

mRNA and Protein(s)

  1. NM_001385197.1 → NP_001372126.1  non-receptor tyrosine-protein kinase TYK2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:892 → 1137
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001385198.1 → NP_001372127.1  non-receptor tyrosine-protein kinase TYK2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:892 → 1124
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001385199.1 → NP_001372128.1  non-receptor tyrosine-protein kinase TYK2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05080
    Location:830 → 1112
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:586 → 805
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001385200.1 → NP_001372129.1  non-receptor tyrosine-protein kinase TYK2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05076
    Location:589 → 866
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:891 → 1173
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain

  5. NM_001385201.1 → NP_001372130.1  non-receptor tyrosine-protein kinase TYK2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05076
    Location:523 → 801
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:826 → 1108
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:371 → 468
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 371
    PH-like; Pleckstrin homology-like domain

  6. NM_001385202.1 → NP_001372131.1  non-receptor tyrosine-protein kinase TYK2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05080
    Location:864 → 1146
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:589 → 839
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001385203.1 → NP_001372132.1  non-receptor tyrosine-protein kinase TYK2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:919 → 1201
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain

  8. NM_001385204.1 → NP_001372133.1  non-receptor tyrosine-protein kinase TYK2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05080
    Location:962 → 1244
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:589 → 937
    PKc_like; Protein Kinases, catalytic domain

  9. NM_001385205.1 → NP_001372134.1  non-receptor tyrosine-protein kinase TYK2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05076
    Location:559 → 837
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:862 → 1144
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:255 → 402
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 236
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:407 → 504
    SH2; Src homology 2 (SH2) domain

  10. NM_001385206.1 → NP_001372135.1  non-receptor tyrosine-protein kinase TYK2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05076
    Location:547 → 825
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:850 → 1132
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 490
    SH2; Src homology 2 (SH2) domain

  11. NM_001385207.1 → NP_001372136.1  non-receptor tyrosine-protein kinase TYK2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011557
    Conserved Domains (6) summary
    cd05080
    Location:886 → 1168
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam17887
    Location:285 → 432
    Jak1_Phl; Jak1 pleckstrin homology-like domain
    pfam18377
    Location:143 → 266
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:28 → 125
    FERM_F1; FERM F1 ubiquitin-like domain
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:584 → 861
    PKc_like; Protein Kinases, catalytic domain

  12. NM_003331.5 → NP_003322.3  non-receptor tyrosine-protein kinase TYK2 isoform 2

    See identical proteins and their annotated locations for NP_003322.3

    Status: REVIEWED

    Source sequence(s)
    AK308360, BC014243, DA864169
    Consensus CDS
    CCDS12236.1
    UniProtKB/Swiss-Prot
    P29597
    UniProtKB/TrEMBL
    A0A024R7E4
    Related
    ENSP00000431885.1, ENST00000525621.6
    Conserved Domains (7) summary
    smart00219
    Location:897 → 1169
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:892 → 1174
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:589 → 866
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10350528..10380572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528245.1 → XP_011526547.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    See identical proteins and their annotated locations for XP_011526547.1

    UniProtKB/Swiss-Prot
    P29597
    UniProtKB/TrEMBL
    A0A024R7E4
    Related
    ENSP00000264818.6, ENST00000264818.10
    Conserved Domains (7) summary
    smart00219
    Location:897 → 1169
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:28 → 273
    B41; Band 4.1 homologues
    cd05076
    Location:589 → 867
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:892 → 1174
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:589 → 866
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:437 → 534
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:270 → 437
    PH-like; Pleckstrin homology-like domain

  2. XM_011528246.3 → XP_011526548.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    See identical proteins and their annotated locations for XP_011526548.1

    Conserved Domains (7) summary
    smart00219
    Location:798 → 1070
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:2 → 174
    B41; Band 4.1 homologues
    cd05076
    Location:490 → 768
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:793 → 1075
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:490 → 767
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:338 → 435
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:171 → 338
    PH-like; Pleckstrin homology-like domain

  3. XM_011528247.1 → XP_011526549.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    See identical proteins and their annotated locations for XP_011526549.1

    Related
    ENSP00000433203.1, ENST00000524462.5
    Conserved Domains (7) summary
    smart00219
    Location:798 → 1070
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:2 → 174
    B41; Band 4.1 homologues
    cd05076
    Location:490 → 768
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:793 → 1075
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:490 → 767
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:338 → 435
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:171 → 338
    PH-like; Pleckstrin homology-like domain

  4. XM_011528251.1 → XP_011526553.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

    Conserved Domains (4) summary
    smart00219
    Location:316 → 588
    TyrKc; Tyrosine kinase, catalytic domain
    cd05080
    Location:311 → 593
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:49 → 285
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:50 → 286
    PKc_like; Protein Kinases, catalytic domain

  5. XM_011528249.2 → XP_011526551.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

    Conserved Domains (5) summary
    smart00219
    Location:455 → 727
    TyrKc; Tyrosine kinase, catalytic domain
    cd05076
    Location:147 → 425
    PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    cd05080
    Location:450 → 732
    PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
    pfam07714
    Location:147 → 424
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:15 → 92
    SH2; Src homology 2 (SH2) domain

RNA

  1. XR_002958353.1 RNA Sequence

  2. XR_001753750.1 RNA Sequence

  3. XR_001753751.1 RNA Sequence

  4. XR_001753752.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29597.3 GenPept UniProtKB/Swiss-Prot:P29597

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