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DIRC3 disrupted in renal carcinoma 3 [ Homo sapiens (human) ]

Gene ID: 729582, updated on 26-Oct-2023

Summary

Official Symbol
DIRC3provided by HGNC
Official Full Name
disrupted in renal carcinoma 3provided by HGNC
Primary source
HGNC:HGNC:17805
See related
Ensembl:ENSG00000231672 MIM:608262; AllianceGenome:HGNC:17805
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
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Genomic context

See DIRC3 in Genome Data Viewer
Location:
2q35
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (217284019..217790443, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (217766488..218273757, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218148742..218621316, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:218073575-218074414 Neighboring gene uncharacterized LOC105373872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17104 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:218082948-218083116 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:218088086-218089285 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:218125637-218126836 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:218134772-218135400 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:218156138-218156638 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:218156639-218157139 Neighboring gene RN7SK pseudogene 43 Neighboring gene DIRC3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 8768 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218199087-218199799 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:218234719-218235918 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56988 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56989 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56990 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56991 Neighboring gene uncharacterized LOC124907981 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56992 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:218291011-218292210 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:218365243-218365794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12307 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:218416177-218416745 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:218419796-218420396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218474359-218475066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17105 Neighboring gene ATPase H+/K+ transporting non-gastric alpha2 subunit pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12308 Neighboring gene Sharpr-MPRA regulatory region 7557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218661013-218661513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17109 Neighboring gene RPL7L1 pseudogene 9 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:218678100-218679299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218684858-218685358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218737749-218738250 Neighboring gene small nucleolar RNA, H/ACA box 115 Neighboring gene tensin 1 Neighboring gene Sharpr-MPRA regulatory region 15318 Neighboring gene microRNA 6809

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Discovery of common variants associated with low TSH levels and thyroid cancer risk.
EBI GWAS Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog
Genome-wide association study on differentiated thyroid cancer.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ14199

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026597.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
  2. NR_186292.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
  3. NR_186293.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009469, AC009492, AC010886, AC011235
  4. NR_186295.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
  5. NR_186296.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009469, AC009492, AC011235
  6. NR_186298.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009469, AC009492, AC011235
  7. NR_186299.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
  8. NR_186300.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
  9. NR_186301.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009469, AC009492, AC011235
  10. NR_186302.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
  11. NR_186303.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
  12. NR_186304.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009492, AC010886, AC011235
    Related
    ENST00000474063.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    217284019..217790443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    217766488..218273757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)