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TMEM242 transmembrane protein 242 [ Homo sapiens (human) ]

Gene ID: 729515, updated on 9-Jun-2025
Official Symbol
TMEM242provided by HGNC
Official Full Name
transmembrane protein 242provided by HGNC
Primary source
HGNC:HGNC:17206
See related
Ensembl:ENSG00000215712 MIM:620721; AllianceGenome:HGNC:17206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM033; C6orf35
Summary
Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in brain (RPKM 5.6), heart (RPKM 4.6) and 25 other tissues See more
Orthologs
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See TMEM242 in Genome Data Viewer
Location:
6q25.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (157289025..157323519, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (158494801..158565506, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (157710057..157744551, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157548108-157548608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157548609-157549109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157552291-157552791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157638855-157639639 Neighboring gene uncharacterized LOC105378075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157611546-157612252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157694329-157695161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157695162-157695993 Neighboring gene uncharacterized LOC124901551 Neighboring gene lactate dehydrogenase A like 6F, pseudogene Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157731297-157731836 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157731837-157732374 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157733661-157734653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157734654-157735645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25330 Neighboring gene uncharacterized LOC105378076 Neighboring gene TMEM242 divergent transcript

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ10029, MGC34308

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transmembrane protein 242
Names
UPF0463 transmembrane protein C6orf35

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018452.6NP_060922.2  transmembrane protein 242

    See identical proteins and their annotated locations for NP_060922.2

    Status: VALIDATED

    Source sequence(s)
    AL390955, BX284653
    Consensus CDS
    CCDS43519.1
    UniProtKB/Swiss-Prot
    B9EJD0, Q9NWH2, Q9NZ88, Q9P094
    UniProtKB/TrEMBL
    Q5T2S1
    Related
    ENSP00000383594.3, ENST00000400788.9
    Conserved Domains (1) summary
    pfam07096
    Location:10124
    DUF1358; Protein of unknown function (DUF1358)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    157289025..157323519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    158494801..158565506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)