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Ift25 intraflagellar transport 25 [ Mus musculus (house mouse) ]

Gene ID: 72938, updated on 24-Sep-2025
Official Symbol
Ift25provided by MGI
Official Full Name
intraflagellar transport 25provided by MGI
Primary source
MGI:MGI:1920188
See related
Ensembl:ENSMUSG00000063172 AllianceGenome:MGI:1920188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP25; Hspb11; 2900042B11Rik
Summary
Predicted to enable metal ion binding activity. Involved in kidney development; smoothened signaling pathway; and spermatogenesis. Acts upstream of or within several processes, including left/right axis specification; lung development; and skeletal system development. Located in centrosome and cilium. Part of intraciliary transport particle B. Is expressed in embryo; germ cell of ovary; and secondary heart field. Orthologous to human IFT25 (intraflagellar transport 25). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in CNS E14 (RPKM 1.3), placenta adult (RPKM 1.3) and 24 other tissues See more
Orthologs
human all
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See Ift25 in Genome Data Viewer
Location:
4 C7; 4 50.18 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107110889..107137135)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107253593..107284497)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 1 Neighboring gene leucine rich repeat containing 42 Neighboring gene STARR-positive B cell enhancer ABC_E4642 Neighboring gene Yip1 domain family, member 1 Neighboring gene deiodinase, iodothyronine, type I Neighboring gene replication factor C (activator 1) 5 pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice. Zhang Y, et al. Dev Biol, 2017 Dec 1. PMID 28964737, Free PMC Article
  2. IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation. Liu H, et al. Biol Reprod, 2017 May 1. PMID 28430876, Free PMC Article
  3. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Desai PB, et al. Mech Dev, 2018 Jun. PMID 29626631, Free PMC Article
  4. Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice. Wang JJ, et al. PLoS Biol, 2020 Dec. PMID 33351795, Free PMC Article
  5. BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia. Monis WJ, et al. J Cell Biol, 2017 Jul 3. PMID 28576874, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This work indicates that IFT25 and IFT27 are important players in the early development of the kidney and suggest that duplex kidney is part of the ciliopathy spectrum.
    Title: Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.
  2. fFndings suggest that like IFT25, IFT27, even though not required for ciliogenesis in somatic cells, is essential for sperm flagella formation, sperm function, and male fertility in mice. IFT25 and IFT27 control sperm formation/function through many common mechanisms, but IFT25 has additional roles beyond IFT27.
    Title: Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice.
  3. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.
    Title: IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intraciliary anterograde transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within intraciliary transport IC
Inferred by Curator
more info
 PubMed 
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within left/right axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cilium TAS
Traceable Author Statement
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
 PubMed 
part_of intraciliary transport particle B IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle B TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
intraflagellar transport protein 25 homolog
Names
heat shock protein beta-11
heat shock protein family B (small), member 11
placental protein 25 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355459.1 → NP_001342388.1  intraflagellar transport protein 25 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AA000737, AK013636, BB759869, BE863784
    Consensus CDS
    CCDS18435.1
    UniProtKB/Swiss-Prot
    Q3TZR2, Q9D6H2
    Related
    ENSMUSP00000102360.2, ENSMUST00000106749.8
    Conserved Domains (1) summary
    cl23730
    Location:19 → 121
    F5_F8_type_C; F5/8 type C domain

  2. NM_001355460.1 → NP_001342389.1  intraflagellar transport protein 25 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BB759869, BE863784
    Consensus CDS
    CCDS18435.1
    UniProtKB/Swiss-Prot
    Q3TZR2, Q9D6H2
    Related
    ENSMUSP00000118617.2, ENSMUST00000152717.8
    Conserved Domains (1) summary
    cl23730
    Location:19 → 121
    F5_F8_type_C; F5/8 type C domain

  3. NM_028394.3 → NP_082670.1  intraflagellar transport protein 25 homolog

    See identical proteins and their annotated locations for NP_082670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AA000737, AA939607, BB759869, BY309412
    Consensus CDS
    CCDS18435.1
    UniProtKB/Swiss-Prot
    Q3TZR2, Q9D6H2
    Related
    ENSMUSP00000048810.8, ENSMUST00000046558.8
    Conserved Domains (1) summary
    cl23730
    Location:19 → 121
    F5_F8_type_C; F5/8 type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107110889..107137135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320398.3 → XP_017175887.1  intraflagellar transport protein 25 homolog isoform X1

    UniProtKB/TrEMBL
    Q8VDG4
    Related
    ENSMUST00000156934.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6H2.2 GenPept UniProtKB/Swiss-Prot:Q9D6H2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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