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OC90 otoconin 90 [ Homo sapiens (human) ]

Gene ID: 729330, updated on 23-Nov-2021

Summary

Official Symbol
OC90provided by HGNC
Official Full Name
otoconin 90provided by HGNC
Primary source
HGNC:HGNC:8100
See related
Ensembl:ENSG00000253117 MIM:601658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLA2L
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OC90 in Genome Data Viewer
Location:
8q24.22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (132024216..132059382, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (133036463..133071629, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986976 Neighboring gene EFR3 homolog A Neighboring gene Sharpr-MPRA regulatory region 9765 Neighboring gene HERV-H LTR-associating 1 Neighboring gene potassium voltage-gated channel subfamily Q member 3 Neighboring gene uncharacterized LOC107986977

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in otolith mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
otoconin-90
Names
phospholipase A2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080399.3NP_001073868.2  otoconin-90 precursor

    Status: VALIDATED

    Source sequence(s)
    AC092817, AC100868, AK297911
    Consensus CDS
    CCDS47919.1
    UniProtKB/Swiss-Prot
    Q02509
    Related
    ENSP00000254627.3, ENST00000254627.4
    Conserved Domains (1) summary
    cd04707
    Location:307423
    otoconin_90; otoconin_90: Phospholipase A2-like domains present in otoconin-90 and otoconin-95, mammal proteins that are principal matrix proteins of calcitic otoconia. Interactions involving otoconin-90 may trigger or constitute key events in otoconia formation. The ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    132024216..132059382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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