Format

Send to:

Choose Destination

TNFRSF4 TNF receptor superfamily member 4 [ Homo sapiens (human) ]

Gene ID: 7293, updated on 6-Jan-2019

Summary

Official Symbol
TNFRSF4provided by HGNC
Official Full Name
TNF receptor superfamily member 4provided by HGNC
Primary source
HGNC:HGNC:11918
See related
Ensembl:ENSG00000186827 MIM:600315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX40; ACT35; CD134; IMD16; TXGP1L
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 2.7), lymph node (RPKM 1.6) and 14 other tissues See more
Orthologs

Genomic context

See TNFRSF4 in Genome Data Viewer
Location:
1p36.33
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1211326..1216812, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1146706..1149703, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TTLL10 antisense RNA 1 Neighboring gene tubulin tyrosine ligase like 10 Neighboring gene TNF receptor superfamily member 18 Neighboring gene stromal cell derived factor 4 Neighboring gene beta-1,3-galactosyltransferase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Immunodeficiency 16
MedGen: C3810053 OMIM: 615593 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tumor necrosis factor receptor superfamily, member 4 (TNFRSF4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    Downstream signaling in naive CD8+ T cells, organism-specific biosystem
    Downstream signaling in naive CD8+ T cells
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
    TNFR2 non-canonical NF-kB pathway, organism-specific biosystemTumor necrosis factor-alpha (TNFA) exerts a wide range of biological effects through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Under normal physiological conditions TNFR2 exhibits more restr...
  • TNFs bind their physiological receptors, organism-specific biosystem (from REACTOME)
    TNFs bind their physiological receptors, organism-specific biosystemMembers of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquir...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tumor necrosis factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of activation-induced cell death of T cells IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cytokine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immunoglobulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of immunoglobulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 4
Names
ACT35 antigen
ATC35 antigen
CD134 antigen
OX40 antigen
OX40 cell surface antigen
OX40 homologue
OX40L receptor
TAX transcriptionally-activated glycoprotein 1 receptor
lymphoid activation antigene ACT35
tax-transcriptionally activated glycoprotein 1 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046896.1 RefSeqGene

    Range
    5486..8299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003327.4NP_003318.1  tumor necrosis factor receptor superfamily member 4 precursor

    See identical proteins and their annotated locations for NP_003318.1

    Status: REVIEWED

    Source sequence(s)
    BC105070
    Consensus CDS
    CCDS11.1
    UniProtKB/Swiss-Prot
    P43489
    Related
    ENSP00000368538.3, ENST00000379236.3
    Conserved Domains (1) summary
    cd13406
    Location:29170
    TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    1211326..1216812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002232.1XP_016857721.1  tumor necrosis factor receptor superfamily member 4 isoform X4

    UniProtKB/Swiss-Prot
    P43489
    Conserved Domains (1) summary
    cd13406
    Location:29170
    TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
  2. XM_011542076.2XP_011540378.1  tumor necrosis factor receptor superfamily member 4 isoform X3

    Conserved Domains (1) summary
    cl22855
    Location:95174
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  3. XM_017002231.1XP_016857720.1  tumor necrosis factor receptor superfamily member 4 isoform X2

    Conserved Domains (1) summary
    cd13406
    Location:29170
    TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
  4. XM_011542075.2XP_011540377.1  tumor necrosis factor receptor superfamily member 4 isoform X2

    Conserved Domains (1) summary
    cd13406
    Location:29170
    TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
  5. XM_011542074.2XP_011540376.1  tumor necrosis factor receptor superfamily member 4 isoform X1

    See identical proteins and their annotated locations for XP_011540376.1

    Conserved Domains (1) summary
    cl22855
    Location:95174
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  6. XM_011542077.2XP_011540379.1  tumor necrosis factor receptor superfamily member 4 isoform X5

    Conserved Domains (1) summary
    cl22855
    Location:2470
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Support Center