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Macrod2 mono-ADP ribosylhydrolase 2 [ Mus musculus (house mouse) ]

Gene ID: 72899, updated on 3-Apr-2024

Summary

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Official Symbol
Macrod2provided by MGI
Official Full Name
mono-ADP ribosylhydrolase 2provided by MGI
Primary source
MGI:MGI:1920149
See related
Ensembl:ENSMUSG00000068205 AllianceGenome:MGI:1920149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110033L15Rik; 2610107G07Rik; 2900006F19Rik
Summary
Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Acts upstream of or within brain development and response to bacterium. Predicted to be located in nucleolus. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Orthologous to human MACROD2 (mono-ADP ribosylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.9), frontal lobe adult (RPKM 2.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F3- G1; 2 69.2 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (140237223..142234886)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (140395303..142392966)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05847 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5 Neighboring gene predicted gene, 52594 Neighboring gene STARR-positive B cell enhancer mm9_chr2:140253034-140253335 Neighboring gene sel-1 suppressor of lin-12-like 2 (C. elegans) Neighboring gene STARR-seq mESC enhancer starr_05848 Neighboring gene STARR-seq mESC enhancer starr_05850 Neighboring gene predicted gene, 23846 Neighboring gene STARR-seq mESC enhancer starr_05851 Neighboring gene STARR-seq mESC enhancer starr_05853 Neighboring gene fibronectin leucine rich transmembrane protein 3 Neighboring gene STARR-seq mESC enhancer starr_05855 Neighboring gene STARR-seq mESC enhancer starr_05856 Neighboring gene zinc finger, CCHC domain containing 9, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05857 Neighboring gene mono-ADP ribosylhydrolase 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05858 Neighboring gene STARR-seq mESC enhancer starr_05859 Neighboring gene STARR-seq mESC enhancer starr_05861 Neighboring gene STARR-seq mESC enhancer starr_05862 Neighboring gene predicted gene, 25583 Neighboring gene STARR-seq mESC enhancer starr_05863 Neighboring gene STARR-seq mESC enhancer starr_05864 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_05865 Neighboring gene STARR-seq mESC enhancer starr_05866 Neighboring gene STARR-seq mESC enhancer starr_05867 Neighboring gene STARR-seq mESC enhancer starr_05871 Neighboring gene STARR-seq mESC enhancer starr_05872 Neighboring gene STARR-seq mESC enhancer starr_05873 Neighboring gene ribosomal protein L26, pseudogene 5 Neighboring gene RNA binding motif protein, X-linked 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. Lo Re O, et al. Front Genet, 2018. PMID 30619475, Free PMC Article
  2. Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice. Crawford K, et al. Cells, 2021 Feb 10. PMID 33578760, Free PMC Article
  3. The C20orf133 gene is disrupted in a patient with Kabuki syndrome. Maas NM, et al. J Med Genet, 2007 Sep. PMID 17586838, Free PMC Article
  4. Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2. Ito H, et al. Dev Neurosci, 2018. PMID 30227424
  5. MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors. Sakthianandeswaren A, et al. Cancer Discov, 2018 Aug. PMID 29880585

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
    Title: Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
  2. MacroD2 is expressed and may have a physiological role in the central nervous system during brain development
    Title: Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC100276

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP-ribosylglutamate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-ribosylglutamate hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peptidyl-glutamate ADP-deribosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-glutamate ADP-deribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein de-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleoside metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleoside metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribose glycohydrolase MACROD2
Names
MACRO domain containing 2
MACRO domain-containing protein 2
O-acetyl-ADP-ribose deacetylase MACROD2
[Protein ADP-ribosylaspartate] hydrolase MACROD2
[Protein ADP-ribosylglutamate] hydrolase
[Protein ADP-ribosylglutamate] hydrolase MACROD2
NP_001013824.2
NP_001393313.1
NP_001393314.1
NP_001393315.1
NP_001393316.1
NP_001393317.1
NP_001393318.1
NP_001393319.1
NP_001393320.1
NP_001393321.1
NP_001393322.1
NP_001393323.1
NP_001393324.1
NP_001393325.1
NP_001393326.1
NP_001393327.1
NP_082663.1
XP_006500314.1
XP_006500316.1
XP_011238096.1
XP_017174774.1
XP_036018502.1
XP_036018504.1
XP_036018505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013802.4 → NP_001013824.2  ADP-ribose glycohydrolase MACROD2 isoform 1

    See identical proteins and their annotated locations for NP_001013824.2

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
    Consensus CDS
    CCDS50733.1
    UniProtKB/Swiss-Prot
    Q3UYG8
    UniProtKB/TrEMBL
    A2AS33
    Related
    ENSMUSP00000105691.2, ENSMUST00000110064.8
    Conserved Domains (2) summary
    COG2110
    Location:70 → 239
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd02908
    Location:71 → 237
    Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

  2. NM_001406384.1 → NP_001393313.1  ADP-ribose glycohydrolase MACROD2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  3. NM_001406385.1 → NP_001393314.1  ADP-ribose glycohydrolase MACROD2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  4. NM_001406386.1 → NP_001393315.1  ADP-ribose glycohydrolase MACROD2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  5. NM_001406387.1 → NP_001393316.1  ADP-ribose glycohydrolase MACROD2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  6. NM_001406388.1 → NP_001393317.1  ADP-ribose glycohydrolase MACROD2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  7. NM_001406389.1 → NP_001393318.1  ADP-ribose glycohydrolase MACROD2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  8. NM_001406390.1 → NP_001393319.1  ADP-ribose glycohydrolase MACROD2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  9. NM_001406391.1 → NP_001393320.1  ADP-ribose glycohydrolase MACROD2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  10. NM_001406392.1 → NP_001393321.1  ADP-ribose glycohydrolase MACROD2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  11. NM_001406393.1 → NP_001393322.1  ADP-ribose glycohydrolase MACROD2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
    Related
    ENSMUSP00000105694.2, ENSMUST00000110067.8

  12. NM_001406394.1 → NP_001393323.1  ADP-ribose glycohydrolase MACROD2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

  13. NM_001406395.1 → NP_001393324.1  ADP-ribose glycohydrolase MACROD2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL837516, AL844562, AL844582, AL845530, AL929027, AL929443

  14. NM_001406396.1 → NP_001393325.1  ADP-ribose glycohydrolase MACROD2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL928700, AL929027
    UniProtKB/TrEMBL
    B1AW12
    Related
    ENSMUSP00000105690.2, ENSMUST00000110063.8

  15. NM_001406397.1 → NP_001393326.1  ADP-ribose glycohydrolase MACROD2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL928700, AL929027
    Related
    ENSMUST00000154505.8

  16. NM_001406398.1 → NP_001393327.1  ADP-ribose glycohydrolase MACROD2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AL731795, AL928700, AL929027

  17. NM_028387.2 → NP_082663.1  ADP-ribose glycohydrolase MACROD2 isoform 2

    See identical proteins and their annotated locations for NP_082663.1

    Status: VALIDATED

    Source sequence(s)
    AL731795
    Consensus CDS
    CCDS16805.1
    UniProtKB/TrEMBL
    Q9D117
    Related
    ENSMUSP00000041780.8, ENSMUST00000043836.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    140237223..142234886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162611.1 → XP_036018504.1  ADP-ribose glycohydrolase MACROD2 isoform X14

    UniProtKB/TrEMBL
    A2AS33
    Conserved Domains (1) summary
    cd02908
    Location:71 → 237
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

  2. XM_006500251.3 → XP_006500314.1  ADP-ribose glycohydrolase MACROD2 isoform X11

    UniProtKB/TrEMBL
    A2AS33
    Conserved Domains (2) summary
    COG5271
    Location:243 → 430
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    PRK00431
    Location:71 → 239
    PRK00431; ADP-ribose-binding protein

  3. XM_011239794.2 → XP_011238096.1  ADP-ribose glycohydrolase MACROD2 isoform X8

    UniProtKB/TrEMBL
    A2AS33
    Conserved Domains (1) summary
    cl00019
    Location:71 → 200
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

  4. XM_036162609.1 → XP_036018502.1  ADP-ribose glycohydrolase MACROD2 isoform X9

    UniProtKB/TrEMBL
    A2AS33
    Conserved Domains (2) summary
    cd02908
    Location:71 → 198
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
    NF033845
    Location:289 → 430
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  5. XM_036162612.1 → XP_036018505.1  ADP-ribose glycohydrolase MACROD2 isoform X16

    UniProtKB/TrEMBL
    A2AS33
    Conserved Domains (2) summary
    cd02908
    Location:71 → 198
    Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
    NF033845
    Location:205 → 417
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

  6. XM_017319285.2 → XP_017174774.1  ADP-ribose glycohydrolase MACROD2 isoform X13

    UniProtKB/TrEMBL
    A2AS33
    Conserved Domains (1) summary
    cl00019
    Location:70 → 189
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

  7. XM_006500253.3 → XP_006500316.1  ADP-ribose glycohydrolase MACROD2 isoform X15

    Related
    ENSMUST00000138786.2
    Conserved Domains (1) summary
    cl00019
    Location:42 → 184
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UYG8.1 GenPept UniProtKB/Swiss-Prot:Q3UYG8

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