U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Setd5 SET domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 72895, updated on 8-Dec-2022

Summary

Official Symbol
Setd5provided by MGI
Official Full Name
SET domain containing 5provided by MGI
Primary source
MGI:MGI:1920145
See related
Ensembl:ENSMUSG00000034269 AllianceGenome:MGI:1920145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1757; C330007C20; 2900045N06Rik
Summary
Enables histone methyltransferase activity (H3-K36 specific) and histone methyltransferase activity (H3-K9 specific). Involved in several processes, including histone H3-K36 trimethylation; regulation of DNA-templated transcription, elongation; and regulation of histone acetylation. Located in euchromatin and nucleus. Part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 23. Orthologous to human SETD5 (SET domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 17.8), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Setd5 in Genome Data Viewer
Location:
6; 6 E3
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113054326..113130393)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113077262..113153432)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene THUMP domain containing 3 Neighboring gene gene trap ROSA 26, Philippe Soriano Neighboring gene predicted gene, 22591 Neighboring gene lipoma HMGIC fusion partner-like protein 4 Neighboring gene myotubularin related protein 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10707, MGC90828

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K36 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3K9 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K9 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables histone lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase SETD5
Names
SET domain-containing protein 5
NP_082661.1
NP_766593.1
XP_006506740.1
XP_011239782.1
XP_011239784.1
XP_011239786.1
XP_011239787.1
XP_017177260.1
XP_017177261.1
XP_030111467.1
XP_030111468.1
XP_030111469.1
XP_030111470.1
XP_030111471.1
XP_030111472.1
XP_030111473.1
XP_030111474.1
XP_030111476.1
XP_030111477.1
XP_030111478.1
XP_030111480.1
XP_030111481.1
XP_030111482.1
XP_030111483.1
XP_030111484.1
XP_036008223.1
XP_036008224.1
XP_036008225.1
XP_036008226.1
XP_036008227.1
XP_036008228.1
XP_036008229.1
XP_036008230.1
XP_036008231.1
XP_036008232.1
XP_036008233.1
XP_036008234.1
XP_036008235.1
XP_036008236.1
XP_036008237.1
XP_036008238.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028385.1NP_082661.1  histone-lysine N-methyltransferase SETD5 isoform 1

    See identical proteins and their annotated locations for NP_082661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AK122551
    Consensus CDS
    CCDS20411.1
    UniProtKB/Swiss-Prot
    Q5XJV7, Q8BX30
    Related
    ENSMUSP00000047398.6, ENSMUST00000042889.12
    Conserved Domains (1) summary
    smart00317
    Location:286395
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  2. NM_173005.1NP_766593.1  histone-lysine N-methyltransferase SETD5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2 which has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK053541, BC083184, BE446905, BF456249
    Consensus CDS
    CCDS90096.1
    UniProtKB/Swiss-Prot
    Q5XJV7
    Related
    ENSMUSP00000108780.2, ENSMUST00000113155.2
    Conserved Domains (1) summary
    cd19181
    Location:285434
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113054326..113130393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241485.4XP_011239787.1  histone-lysine N-methyltransferase SETD5 isoform X6

    See identical proteins and their annotated locations for XP_011239787.1

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  2. XM_011241480.4XP_011239782.1  histone-lysine N-methyltransferase SETD5 isoform X1

    See identical proteins and their annotated locations for XP_011239782.1

    Conserved Domains (1) summary
    cd19181
    Location:292441
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  3. XM_011241482.4XP_011239784.1  histone-lysine N-methyltransferase SETD5 isoform X2

    UniProtKB/Swiss-Prot
    Q5XJV7
    Related
    ENSMUSP00000108782.2, ENSMUST00000113157.8
    Conserved Domains (1) summary
    cd19181
    Location:285434
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  4. XM_030255607.2XP_030111467.1  histone-lysine N-methyltransferase SETD5 isoform X3

    Conserved Domains (1) summary
    cd19181
    Location:273422
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  5. XM_030255620.2XP_030111480.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  6. XM_036152332.1XP_036008225.1  histone-lysine N-methyltransferase SETD5 isoform X1

    Conserved Domains (1) summary
    cd19181
    Location:292441
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  7. XM_030255612.2XP_030111472.1  histone-lysine N-methyltransferase SETD5 isoform X4

    Conserved Domains (1) summary
    cd19181
    Location:247396
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  8. XM_036152333.1XP_036008226.1  histone-lysine N-methyltransferase SETD5 isoform X2

    Conserved Domains (1) summary
    cd19181
    Location:285434
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  9. XM_036152331.1XP_036008224.1  histone-lysine N-methyltransferase SETD5 isoform X1

    Conserved Domains (1) summary
    cd19181
    Location:292441
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  10. XM_030255613.2XP_030111473.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  11. XM_036152340.1XP_036008233.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  12. XM_030255614.2XP_030111474.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  13. XM_036152338.1XP_036008231.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  14. XM_036152336.1XP_036008229.1  histone-lysine N-methyltransferase SETD5 isoform X4

    Conserved Domains (1) summary
    cd19181
    Location:247396
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  15. XM_036152330.1XP_036008223.1  histone-lysine N-methyltransferase SETD5 isoform X1

    Conserved Domains (1) summary
    cd19181
    Location:292441
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  16. XM_036152334.1XP_036008227.1  histone-lysine N-methyltransferase SETD5 isoform X3

    Conserved Domains (1) summary
    cd19181
    Location:273422
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  17. XM_036152339.1XP_036008232.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  18. XM_030255622.2XP_030111482.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  19. XM_030255609.2XP_030111469.1  histone-lysine N-methyltransferase SETD5 isoform X4

    Conserved Domains (1) summary
    cd19181
    Location:247396
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  20. XM_006506677.5XP_006506740.1  histone-lysine N-methyltransferase SETD5 isoform X1

    See identical proteins and their annotated locations for XP_006506740.1

    Conserved Domains (1) summary
    cd19181
    Location:292441
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  21. XM_030255617.2XP_030111477.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  22. XM_030255621.2XP_030111481.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  23. XM_011241484.4XP_011239786.1  histone-lysine N-methyltransferase SETD5 isoform X4

    Conserved Domains (1) summary
    cd19181
    Location:247396
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  24. XM_036152341.1XP_036008234.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  25. XM_036152337.1XP_036008230.1  histone-lysine N-methyltransferase SETD5 isoform X5

    Conserved Domains (1) summary
    cd19181
    Location:228377
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  26. XM_017321772.3XP_017177261.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  27. XM_017321771.3XP_017177260.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  28. XM_030255616.2XP_030111476.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  29. XM_036152335.1XP_036008228.1  histone-lysine N-methyltransferase SETD5 isoform X3

    Conserved Domains (1) summary
    cd19181
    Location:273422
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  30. XM_030255611.2XP_030111471.1  histone-lysine N-methyltransferase SETD5 isoform X4

    Conserved Domains (1) summary
    cd19181
    Location:247396
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  31. XM_036152343.1XP_036008236.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  32. XM_036152344.1XP_036008237.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  33. XM_030255608.2XP_030111468.1  histone-lysine N-methyltransferase SETD5 isoform X3

    Conserved Domains (1) summary
    cd19181
    Location:273422
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  34. XM_030255610.2XP_030111470.1  histone-lysine N-methyltransferase SETD5 isoform X4

    Conserved Domains (1) summary
    cd19181
    Location:247396
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  35. XM_030255618.2XP_030111478.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  36. XM_030255623.2XP_030111483.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  37. XM_030255624.2XP_030111484.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  38. XM_036152345.1XP_036008238.1  histone-lysine N-methyltransferase SETD5 isoform X7

    Conserved Domains (1) summary
    cd19181
    Location:292441
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins
  39. XM_036152342.1XP_036008235.1  histone-lysine N-methyltransferase SETD5 isoform X6

    Conserved Domains (1) summary
    cd19181
    Location:155304
    SET_SETD5; SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins