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PPIAL4F peptidylprolyl isomerase A like 4F [ Homo sapiens (human) ]

Gene ID: 728945, updated on 7-Jan-2024

Summary

Official Symbol
PPIAL4Fprovided by HGNC
Official Full Name
peptidylprolyl isomerase A like 4Fprovided by HGNC
Primary source
HGNC:HGNC:33999
See related
Ensembl:ENSG00000279782 AllianceGenome:HGNC:33999
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PPIAL4F in Genome Data Viewer
Location:
1q21.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (144592893..144593652)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (143472958..143473717, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (148806040..148806799)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985110 Neighboring gene tRNA-Asn (anticodon GTT) 2-8 Neighboring gene long intergenic non-protein coding RNA 1632 Neighboring gene Sharpr-MPRA regulatory region 1883 duplicate 3 Neighboring gene uncharacterized LOC105371215

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase A-like 4F
Names
PPIase A-like 4F
cyclophilin-LC (COAS2) pseudogene
peptidylprolyl isomerase A (cyclophilin A)-like 4F
NP_001157734.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164262.3NP_001157734.2  peptidyl-prolyl cis-trans isomerase A-like 4F

    See identical proteins and their annotated locations for NP_001157734.2

    Status: INFERRED

    Source sequence(s)
    AC253578
    Consensus CDS
    CCDS76202.1
    UniProtKB/Swiss-Prot
    A0A075B759, P0DN26
    UniProtKB/TrEMBL
    A0A0H2UH34
    Related
    ENSP00000485638.1, ENST00000581138.4
    Conserved Domains (1) summary
    cl00197
    Location:4162
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    144592893..144593652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187520.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    104185..104944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    143472958..143473717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_009697.1: Suppressed sequence

    Description
    NG_009697.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.