Format

Send to:

Choose Destination

ZNF736 zinc finger protein 736 [ Homo sapiens (human) ]

Gene ID: 728927, updated on 5-Jan-2022

Summary

Official Symbol
ZNF736provided by HGNC
Official Full Name
zinc finger protein 736provided by HGNC
Primary source
HGNC:HGNC:32467
See related
Ensembl:ENSG00000234444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in testis (RPKM 3.1), bone marrow (RPKM 2.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF736 in Genome Data Viewer
Location:
7q11.21
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (64313961..64356634)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (63774339..63817012)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375323 Neighboring gene uncharacterized LOC105375322 Neighboring gene tripartite motif containing 60 pseudogene 18 Neighboring gene uncharacterized LOC105375321 Neighboring gene uncharacterized LOC105375324

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43489, FLJ44406, DKFZp781H0161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 736
Names
KRAB-containing zinc-finger repressor protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170905.3NP_001164376.1  zinc finger protein 736 isoform 1

    See identical proteins and their annotated locations for NP_001164376.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), which contains the zinc finger domains.
    Source sequence(s)
    AC073270, AK301806, DB048979
    Consensus CDS
    CCDS55114.1
    UniProtKB/Swiss-Prot
    B4DX44
    Related
    ENSP00000400852.1, ENST00000423484.3
    Conserved Domains (5) summary
    smart00349
    Location:463
    KRAB; krueppel associated box
    COG5048
    Location:227383
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:215240
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001294255.2NP_001281184.1  zinc finger protein 736 isoform 2

    See identical proteins and their annotated locations for NP_001281184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and its transcription extends past a splice junction used in variant 1, resulting in a different 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC073270, BC031335, DB048979
    Related
    ENST00000488621.1
    Conserved Domains (2) summary
    smart00349
    Location:463
    KRAB; krueppel associated box
    pfam01352
    Location:443
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    64313961..64356634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center