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CT45A2 cancer/testis antigen family 45 member A2 [ Homo sapiens (human) ]

Gene ID: 728911, updated on 10-Dec-2019

Summary

Official Symbol
CT45A2provided by HGNC
Official Full Name
cancer/testis antigen family 45 member A2provided by HGNC
Primary source
HGNC:HGNC:28400
See related
Ensembl:ENSG00000271449 MIM:300793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT45-2; CT45.2; CT45A8; CT45A9
Summary
This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. [provided by RefSeq, Apr 2014]
Expression
Restricted expression toward testis (RPKM 8.0) See more

Genomic context

See CT45A2 in Genome Data Viewer
Location:
Xq26.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135811668..135820062, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134856887..134874268)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A5 Neighboring gene cancer/testis antigen family 45 member A6 Neighboring gene cancer/testis antigen family 45 member A7 Neighboring gene cancer/testis antigen family 45 member A8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cancer/testis antigen family 45 member A2
Names
Cancer/testis antigen 45A8
Cancer/testis antigen 45A9
Cancer/testis antigen family 45 member A8
Cancer/testis antigen family 45 member A9
cancer/testis antigen 45-2
cancer/testis antigen 45A2
cancer/testis antigen CT45

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021269.2 RefSeqGene

    Range
    5001..13345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152582.7NP_689795.4  cancer/testis antigen family 45 member A2

    See identical proteins and their annotated locations for NP_689795.4

    Status: REVIEWED

    Source sequence(s)
    AC240441
    Consensus CDS
    CCDS76031.1
    UniProtKB/Swiss-Prot
    P0DMV1, P0DMV2, Q5DJT8
    Related
    ENSP00000483619.1, ENST00000612907.1
    Conserved Domains (1) summary
    pfam15300
    Location:122183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135811668..135820062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531389.2XP_011529691.1  cancer/testis antigen family 45 member A2 isoform X1

    See identical proteins and their annotated locations for XP_011529691.1

    UniProtKB/Swiss-Prot
    P0DMV1, P0DMV2, Q5DJT8
    Conserved Domains (1) summary
    pfam15300
    Location:122183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
  2. XM_006724783.2XP_006724846.1  cancer/testis antigen family 45 member A2 isoform X1

    See identical proteins and their annotated locations for XP_006724846.1

    UniProtKB/Swiss-Prot
    P0DMV1, P0DMV2, Q5DJT8
    Conserved Domains (1) summary
    pfam15300
    Location:122183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
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