U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FAM72D family with sequence similarity 72 member D [ Homo sapiens (human) ]

Gene ID: 728833, updated on 13-May-2022

Summary

Official Symbol
FAM72Dprovided by HGNC
Official Full Name
family with sequence similarity 72 member Dprovided by HGNC
Primary source
HGNC:HGNC:33593
See related
Ensembl:ENSG00000215784 MIM:614712; AllianceGenome:HGNC:33593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCUD2
Summary
Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: There is a set of highly related genes in the FAM72 set. This instance was annotated as FAM72A in Build 36.2, based on the evaluation that AB096683, used at that time to define FAM72A, aligned best to AL109844. The definition of FAM72A was changed to the locus on CR407567.2, so this locus was renamed. [13 Feb 2013]
Expression
Broad expression in lymph node (RPKM 4.5), appendix (RPKM 2.4) and 18 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FAM72D in Genome Data Viewer
Location:
1q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145094296..145112696)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144219006..144237402)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (143896448..143914847, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SLIT-ROBO Rho GTPase activating protein 2B Neighboring gene Sharpr-MPRA regulatory region 356 duplicate 2 Neighboring gene Sharpr-MPRA regulatory region 15698 duplicate 2 Neighboring gene Sharpr-MPRA regulatory region 11936 Neighboring gene tRNA-Asn (anticodon GTT) 10-1 Neighboring gene myomegalin-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ97145, MGC57827, MGC182081, MGC182095

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein FAM72D
Names
gastric cancer up-regulated protein 2
gastric cancer up-regulated-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345942.2NP_001332871.1  protein FAM72D isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is the same size but contains a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC242498
    Conserved Domains (1) summary
    pfam14976
    Location:49149
    FAM72; FAM72 protein
  2. NM_207418.3NP_997301.2  protein FAM72D isoform 1

    See identical proteins and their annotated locations for NP_997301.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AB096683, AC242498
    Consensus CDS
    CCDS72855.1
    UniProtKB/Swiss-Prot
    Q6L9T8
    Related
    ENSP00000383682.1, ENST00000400889.3
    Conserved Domains (1) summary
    pfam14976
    Location:6149
    FAM72; FAM72 protein

RNA

  1. NR_144320.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC242498

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145094296..145112696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429806.1XP_047285762.1  protein FAM72D isoform X1

  2. XM_011509962.4XP_011508264.1  protein FAM72D isoform X2

    Conserved Domains (1) summary
    pfam14976
    Location:49149
    FAM72; FAM72 protein
  3. XM_047429809.1XP_047285765.1  protein FAM72D isoform X1

  4. XM_024449521.2XP_024305289.1  protein FAM72D isoform X5

    Conserved Domains (1) summary
    pfam14976
    Location:676
    FAM72; FAM72 protein
  5. XM_024449520.2XP_024305288.1  protein FAM72D isoform X4

    Conserved Domains (1) summary
    pfam14976
    Location:1120
    FAM72; FAM72 protein
  6. XM_047429821.1XP_047285777.1  protein FAM72D isoform X4

  7. XM_011509963.4XP_011508265.1  protein FAM72D isoform X3

    Conserved Domains (1) summary
    pfam14976
    Location:6118
    FAM72; FAM72 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    144219006..144237402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)