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MS4A18 membrane spanning 4-domains A18 [ Homo sapiens (human) ]

Gene ID: 728588, updated on 25-Jan-2022

Summary

Official Symbol
MS4A18provided by HGNC
Official Full Name
membrane spanning 4-domains A18provided by HGNC
Primary source
HGNC:HGNC:37636
See related
Ensembl:ENSG00000214782 AllianceGenome:HGNC:37636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in duodenum (RPKM 4.4) and small intestine (RPKM 0.9) See more
Orthologs
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Genomic context

See MS4A18 in Genome Data Viewer
Location:
11q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60722909..60745028)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60492193..60511686)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369321 Neighboring gene long intergenic non-protein coding RNA 301 Neighboring gene membrane spanning 4-domains A8 Neighboring gene membrane spanning 4-domains A15 Neighboring gene uncharacterized LOC105369322 Neighboring gene membrane spanning 4-domains A10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
membrane-spanning 4-domains subfamily A member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354471.3NP_001341400.1  membrane-spanning 4-domains subfamily A member 18

    Status: VALIDATED

    Source sequence(s)
    AP004243
    Related
    ENSP00000381953.2, ENST00000398983.2
    Conserved Domains (2) summary
    pfam04103
    Location:155244
    CD20; CD20-like family
    cl00232
    Location:287366
    Ribosomal_L19e; Ribosomal protein L19e. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an extended segment. ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60722909..60745028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545421.2XP_011543723.1  membrane-spanning 4-domains subfamily A member 18 isoform X1

    See identical proteins and their annotated locations for XP_011543723.1

    Conserved Domains (2) summary
    pfam04103
    Location:155244
    CD20; CD20-like family
    cl00232
    Location:287366
    Ribosomal_L19e; Ribosomal protein L19e. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an extended segment. ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001310141.1: Suppressed sequence

    Description
    NM_001310141.1: This RefSeq was removed because there is currently insufficient support for the transcript and protein.
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