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OPN1MW2 opsin 1, medium wave sensitive 2 [ Homo sapiens (human) ]

Gene ID: 728458, updated on 13-May-2022

Summary

Official Symbol
OPN1MW2provided by HGNC
Official Full Name
opsin 1, medium wave sensitive 2provided by HGNC
Primary source
HGNC:HGNC:26952
See related
Ensembl:ENSG00000166160 AllianceGenome:HGNC:26952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GOP
Summary
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009]
Expression
Low expression observed in reference dataset See more
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Genomic context

See OPN1MW2 in Genome Data Viewer
Location:
Xq28
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154219756..154233286)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152493394..152506924)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153485225..153498755)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TEX28 pseudogene 2 Neighboring gene opsin 1, medium wave sensitive Neighboring gene TEX28 pseudogene 1 Neighboring gene TEX28 pseudogene 3 Neighboring gene opsin 1, medium wave sensitive 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables photoreceptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of visible light IEA
Inferred from Electronic Annotation
more info
 
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-chromophore linkage IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in photoreceptor disc membrane TAS
Traceable Author Statement
more info
 
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
medium-wave-sensitive opsin 1
Names
green cone photoreceptor pigment
green-sensitive opsin
opsin 1 (cone pigments), medium-wave-sensitive 2
opsin 1 cone pigments medium-wave-sensitive 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048181.3NP_001041646.1  medium-wave-sensitive opsin 1

    See identical proteins and their annotated locations for NP_001041646.1

    Status: REVIEWED

    Source sequence(s)
    AC244097
    Consensus CDS
    CCDS35447.1
    UniProtKB/Swiss-Prot
    P04001, P0DN77, P0DN78
    Related
    ENSP00000358945.4, ENST00000369929.8
    Conserved Domains (2) summary
    pfam00001
    Location:71322
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:61178
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154219756..154233286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152493394..152506924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)