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TSPY8 testis specific protein Y-linked 8 [ Homo sapiens (human) ]

Gene ID: 728403, updated on 5-Jan-2022

Summary

Official Symbol
TSPY8provided by HGNC
Official Full Name
testis specific protein Y-linked 8provided by HGNC
Primary source
HGNC:HGNC:37471
See related
Ensembl:ENSG00000229549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in several processes, including gonadal mesoderm development; nucleosome assembly; and spermatogenesis. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis (RPKM 34.5) See more
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Genomic context

See TSPY8 in Genome Data Viewer
Location:
Yp11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (9357797..9360600)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9195406..9198202)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein Y-linked 4 Neighboring gene family with sequence similarity 197 Y-linked member 8 Neighboring gene family with sequence similarity 197 Y-linked member 7 Neighboring gene testis specific protein Y-linked 7, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific Y-encoded protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243721.2NP_001230650.1  testis-specific Y-encoded protein 8

    See identical proteins and their annotated locations for NP_001230650.1

    Status: VALIDATED

    Source sequence(s)
    AC006158
    Consensus CDS
    CCDS59533.1
    UniProtKB/Swiss-Prot
    P0CW00
    Related
    ENSP00000287721.9, ENST00000287721.13
    Conserved Domains (1) summary
    cl08298
    Location:126288
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    9357797..9360600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272744.4XP_005272801.1  testis-specific Y-encoded protein 8 isoform X1

    UniProtKB/TrEMBL
    A6NGL4
    Related
    ENSP00000372462.1, ENST00000383000.1
    Conserved Domains (1) summary
    cl08298
    Location:103273
    NAP; Nucleosome assembly protein (NAP)
  2. XM_011544005.2XP_011542307.1  testis-specific Y-encoded protein 8 isoform X2

    Conserved Domains (1) summary
    cl08298
    Location:112223
    NAP; Nucleosome assembly protein (NAP)

RNA

  1. XR_949064.2 RNA Sequence

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