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POTEF POTE ankyrin domain family member F [ Homo sapiens (human) ]

Gene ID: 728378, updated on 9-Dec-2022

Summary

Official Symbol
POTEFprovided by HGNC
Official Full Name
POTE ankyrin domain family member Fprovided by HGNC
Primary source
HGNC:HGNC:33905
See related
Ensembl:ENSG00000196604 AllianceGenome:HGNC:33905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACTB; A26C1B; POTEACTIN; POTE2alpha
Summary
Involved in retina homeostasis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 2.4), prostate (RPKM 1.0) and 12 other tissues See more
Orthologs
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Genomic context

See POTEF in Genome Data Viewer
Location:
2q21.1
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130073535..130129222, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130501410..130563122, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (130831108..130886795, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acyl-CoA reductase 2 pseudogene 1 Neighboring gene Kruppel like factor 2 pseudogene 1 Neighboring gene cytochrome P450 family 4 subfamily F member 27, pseudogene Neighboring gene RNA, U6 small nuclear 1049, pseudogene Neighboring gene POTEF antisense RNA 1 Neighboring gene mediator complex subunit 15 pseudogene 9 Neighboring gene coiled-coil domain containing 74B Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene mitotic spindle organizing protein 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human POTE ankyrin domain family, member F (POTEF) at amino acid residues 7-8 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of postsynaptic actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retina homeostasis HEP PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in blood microparticle HDA PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
POTE ankyrin domain family member F
Names
ANKRD26-like family C member 1B
POTE-2 alpha-actin
beta actin
chimeric POTE-actin protein
prostate, ovary, testis expressed protein on chromosome 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099771.2NP_001093241.1  POTE ankyrin domain family member F

    See identical proteins and their annotated locations for NP_001093241.1

    Status: VALIDATED

    Source sequence(s)
    AC018804, AC018865
    Consensus CDS
    CCDS46409.1
    UniProtKB/Swiss-Prot
    A5A3E0, A6NC34
    Related
    ENSP00000386786.2, ENST00000409914.7
    Conserved Domains (6) summary
    smart00268
    Location:7051074
    ACTIN; Actin
    cd00204
    Location:167292
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:177269
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:143193
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:238269
    ANK; ANK repeat [structural motif]
    cl17037
    Location:7011075
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    130073535..130129222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445721.1XP_047301677.1  POTE ankyrin domain family member F isoform X2

    UniProtKB/Swiss-Prot
    A6NC34
  2. XM_017004833.2XP_016860322.1  POTE ankyrin domain family member F isoform X1

  3. XM_017004834.2XP_016860323.1  POTE ankyrin domain family member F isoform X3

  4. XM_017004835.2XP_016860324.1  POTE ankyrin domain family member F isoform X4

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791762.1 Reference GRCh38.p14 PATCHES

    Range
    244068..305780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    130501410..130563122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)