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NXF2B nuclear RNA export factor 2B [ Homo sapiens (human) ]

Gene ID: 728343, updated on 25-Nov-2021

Summary

Official Symbol
NXF2Bprovided by HGNC
Official Full Name
nuclear RNA export factor 2Bprovided by HGNC
Primary source
HGNC:HGNC:23984
See related
Ensembl:ENSG00000269437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCP11X2; bA353J17.1
Summary
This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Jun 2015]
Expression
Restricted expression toward testis (RPKM 9.5) See more
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Genomic context

See NXF2B in Genome Data Viewer
Location:
Xq22.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (102360395..102440008, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101615316..101694929, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene t-complex 11 family, X-linked 1 Neighboring gene leucine rich repeat containing 14 pseudogene Neighboring gene nuclear RNA export factor 2 Neighboring gene t-complex 11 family, X-linked 2 Neighboring gene thymosin beta 15A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20416, FLJ32823, FLJ54838, FLJ98203, DKFZp434B1612, DKFZp686N2036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA export from nucleus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of nuclear RNA export factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of nuclear RNA export factor complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nuclear RNA export factor 2
Names
T-complex protein 11 X-linked protein 2
TAP-like protein 2
cancer/testis antigen 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099686.3NP_001093156.1  nuclear RNA export factor 2

    See identical proteins and their annotated locations for NP_001093156.1

    Status: VALIDATED

    Source sequence(s)
    AC235565, AK000423, AK308255
    Consensus CDS
    CCDS43979.1
    UniProtKB/Swiss-Prot
    Q9GZY0
    Related
    ENSP00000472530.1, ENST00000602195.5
    Conserved Domains (5) summary
    smart00804
    Location:570623
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:229271
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam09162
    Location:121203
    Tap-RNA_bind; Tap, RNA-binding
    pfam13855
    Location:270332
    LRR_8; Leucine rich repeat
    cl09109
    Location:391543
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    102360395..102440008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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