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Ubash3b ubiquitin associated and SH3 domain containing, B [ Mus musculus (house mouse) ]

Gene ID: 72828, updated on 12-Aug-2018

Summary

Official Symbol
Ubash3bprovided by MGI
Official Full Name
ubiquitin associated and SH3 domain containing, Bprovided by MGI
Primary source
MGI:MGI:1920078
See related
Ensembl:ENSMUSG00000032020 Vega:OTTMUSG00000025903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p70; STS-1; TULA-2; BB125008; 2810457I06Rik
Expression
Broad expression in cerebellum adult (RPKM 9.2), CNS E18 (RPKM 4.0) and 19 other tissues See more
Orthologs

Genomic context

See Ubash3b in Genome Data Viewer
Location:
9; 9 A5.1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (41010760..41161692, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (40821724..40965577, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene junctional cadherin complex regulator Neighboring gene ubiquitin specific peptidase 10 pseudogene Neighboring gene cytotoxic and regulatory T cell molecule Neighboring gene predicted gene, 35657 Neighboring gene predicted gene 6885 Neighboring gene RIKEN cDNA 1700063D05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
collagen-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin-associated and SH3 domain-containing protein B
Names
T-cell ubiquitin ligand 2
cbl-interacting protein p70
suppressor of T-cell receptor signaling 1
tyrosine-protein phosphatase STS1/TULA2
NP_789830.1
XP_006510695.1
XP_006510697.1
XP_006510699.1
XP_006510700.1
XP_017169101.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357412.1NP_001344341.1  ubiquitin-associated and SH3 domain-containing protein B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC159820, AK013361
    Conserved Domains (2) summary
    cd07067
    Location:253465
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:123184
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
  2. NM_176860.6NP_789830.1  ubiquitin-associated and SH3 domain-containing protein B isoform 1

    See identical proteins and their annotated locations for NP_789830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159820, AK035764, AK150909
    Consensus CDS
    CCDS23085.1
    UniProtKB/Swiss-Prot
    Q8BGG7
    Related
    ENSMUSP00000043865.8, OTTMUSP00000031634, ENSMUST00000044155.14
    Conserved Domains (3) summary
    cd07067
    Location:375587
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:245306
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cd14301
    Location:2865
    UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    41010760..41161692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510632.2XP_006510695.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

    Conserved Domains (2) summary
    cd07067
    Location:516728
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:386447
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
  2. XM_006510634.3XP_006510697.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

    Conserved Domains (3) summary
    cd07067
    Location:403615
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:273334
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cl21463
    Location:7293
    UBA_like_SF; UBA domain-like superfamily
  3. XM_006510636.3XP_006510699.1  ubiquitin-associated and SH3 domain-containing protein B isoform X3

    Conserved Domains (3) summary
    cd07067
    Location:352564
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:222283
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cl21463
    Location:2142
    UBA_like_SF; UBA domain-like superfamily
  4. XM_006510637.3XP_006510700.1  ubiquitin-associated and SH3 domain-containing protein B isoform X4

    UniProtKB/Swiss-Prot
    Q8BGG7
    Related
    ENSMUSP00000116038.1, OTTMUSP00000031635, ENSMUST00000151485.7, OTTMUST00000063836
    Conserved Domains (2) summary
    cd07067
    Location:253465
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:123184
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
  5. XM_017313612.1XP_017169101.1  ubiquitin-associated and SH3 domain-containing protein B isoform X4

    UniProtKB/Swiss-Prot
    Q8BGG7
    Conserved Domains (2) summary
    cd07067
    Location:253465
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:123184
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
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