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Pard3b par-3 family cell polarity regulator beta [ Mus musculus (house mouse) ]

Gene ID: 72823, updated on 18-Oct-2022

Summary

Official Symbol
Pard3bprovided by MGI
Official Full Name
par-3 family cell polarity regulator betaprovided by MGI
Primary source
MGI:MGI:1919301
See related
Ensembl:ENSMUSG00000052062 AllianceGenome:MGI:1919301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAR3B; PAR3L; Als2cr19; PAR3beta; 1810008K04Rik; 2010002N16Rik; 2810455B10Rik
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to act upstream of or within cell division. Predicted to be located in cell junction. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in brain; genitourinary system; nose; and stomach. Orthologous to human PARD3B (par-3 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.0), colon adult (RPKM 2.1) and 27 other tissues See more
Orthologs
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Genomic context

See Pard3b in Genome Data Viewer
Location:
1; 1 C2
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (61677825..62681443)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (61638667..62642284)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530026F06 gene Neighboring gene predicted gene 11587 Neighboring gene par-3 family cell polarity regulator beta, opposite strand 1 Neighboring gene par-3 family cell polarity regulator beta, opposite strand 2 Neighboring gene predicted gene, 34881 Neighboring gene 40S ribosomal protein S2-like Neighboring gene predicted gene 29083 Neighboring gene neuropilin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
partitioning defective 3 homolog B
Names
PAR3-L protein
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog
par-3 partitioning defective 3 homolog B
partitioning defective 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081050.3NP_001074519.2  partitioning defective 3 homolog B

    See identical proteins and their annotated locations for NP_001074519.2

    Status: VALIDATED

    Source sequence(s)
    AC101661, AL645544, AL645727, AL662815, AL662920
    Consensus CDS
    CCDS48276.1
    UniProtKB/Swiss-Prot
    Q5SV53, Q9CSB4
    UniProtKB/TrEMBL
    Q05B96, Q3URJ9, Q8BKM8
    Related
    ENSMUSP00000074837.4, ENSMUST00000075374.10
    Conserved Domains (3) summary
    smart00228
    Location:380469
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:501589
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1143
    DUF3534; Domain of unknown function (DUF3534)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    61677825..62681443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153731.1XP_036009624.1  partitioning defective 3 homolog B isoform X4

    Conserved Domains (3) summary
    smart00228
    Location:415504
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:536624
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:274
    DUF3534; N-terminal of Par3 and HAL proteins
  2. XM_011238602.4XP_011236904.1  partitioning defective 3 homolog B isoform X3

    Conserved Domains (3) summary
    smart00228
    Location:415504
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:536624
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:274
    DUF3534; N-terminal of Par3 and HAL proteins
  3. XM_006496298.4XP_006496361.1  partitioning defective 3 homolog B isoform X1

    Conserved Domains (3) summary
    smart00228
    Location:415504
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:536624
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:274
    DUF3534; N-terminal of Par3 and HAL proteins
  4. XM_006496299.5XP_006496362.1  partitioning defective 3 homolog B isoform X2

    Conserved Domains (2) summary
    smart00228
    Location:201290
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:322410
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...