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GGTLC3 gamma-glutamyltransferase light chain family member 3 [ Homo sapiens (human) ]

Gene ID: 728226, updated on 5-Aug-2022


Official Symbol
GGTLC3provided by HGNC
Official Full Name
gamma-glutamyltransferase light chain family member 3provided by HGNC
Primary source
See related
Ensembl:ENSG00000274252 MIM:612340; AllianceGenome:HGNC:33426
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
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Genomic context

See GGTLC3 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (18516338..18518166, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20366211..20368028, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987325 Neighboring gene family with sequence similarity 230 member A Neighboring gene transmembrane protein 191B Neighboring gene phosphatidylinositol 4-kinase alpha pseudogene 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
enables molecular_function ND
No biological Data available
more info
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
involved_in leukotriene D4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
putative glutathione hydrolase light chain 3
gamma-glutamyltransferase light chain 3
putative gamma-glutamyltransferase light chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355479.1NP_001342408.1  putative glutathione hydrolase light chain 3

    Status: INFERRED

    Source sequence(s)
    Consensus CDS
    ENSP00000477856.1, ENST00000619998.1
    Conserved Domains (1) summary
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    18516338..18518166 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452264.2XP_024308032.1  putative glutathione hydrolase light chain 3 isoform X1

    Conserved Domains (1) summary
    G_glu_transpept; Gamma-glutamyltranspeptidase
  2. XM_047441480.1XP_047297436.1  putative glutathione hydrolase light chain 3 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_011826.1: Suppressed sequence

    NG_011826.1: This RefSeq was removed because it is now thought that this locus encodes a protein.