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NALF1 NALCN channel auxiliary factor 1 [ Homo sapiens (human) ]

Gene ID: 728215, updated on 22-Sep-2022


Official Symbol
NALF1provided by HGNC
Official Full Name
NALCN channel auxiliary factor 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000204442 MIM:619899; AllianceGenome:HGNC:33877
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLF1; NLF-1; FAM155A
Predicted to contribute to stretch-activated, cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Biased expression in brain (RPKM 13.1), testis (RPKM 1.7) and 7 other tissues See more
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Genomic context

See NALF1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (107163510..107867496, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (106389828..107093540, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (107815858..108519844, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC124903205 Neighboring gene small nucleolar RNA, C/D box 31B Neighboring gene uncharacterized LOC105370353 Neighboring gene uncharacterized LOC112268110 Neighboring gene microRNA 1267 Neighboring gene NALF1 intronic transcript 1 Neighboring gene heparan sulfate glucosamine 3-O-sulfotransferase 4-like Neighboring gene Sharpr-MPRA regulatory region 13792 Neighboring gene abhydrolase domain containing 13 Neighboring gene DNA ligase 4

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

A genome-wide association study for reading and language abilities in two population cohorts.
EBI GWAS Catalog
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
EBI GWAS Catalog
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
EBI GWAS Catalog
Genome-wide association scan of trait depression.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to stretch-activated, cation-selective, calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
NALCN channel auxiliary factor 1
family with sequence similarity 155 member A
transmembrane protein FAM155A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080396.3NP_001073865.1  NALCN channel auxiliary factor 1

    See identical proteins and their annotated locations for NP_001073865.1

    Status: VALIDATED

    Source sequence(s)
    AL136964, AL445204, AW592075, BC157855, DA779672, N69765
    Consensus CDS
    B1AL88, B7Z334
    ENSP00000365080.1, ENST00000375915.4
    Conserved Domains (1) summary
    Mid1; Stretch-activated Ca2+-permeable channel component

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    107163510..107867496 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060937.1 Alternate T2T-CHM13v2.0

    106389828..107093540 complement
    GenBank, FASTA, Sequence Viewer (Graphics)