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RSPH10B2 radial spoke head 10 homolog B2 [ Homo sapiens (human) ]

Gene ID: 728194, updated on 4-Nov-2022

Summary

Official Symbol
RSPH10B2provided by HGNC
Official Full Name
radial spoke head 10 homolog B2provided by HGNC
Primary source
HGNC:HGNC:34385
See related
Ensembl:ENSG00000169402 AllianceGenome:HGNC:34385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein component of the radial spoke head in flagella and motile cilia. Eukaryotic flagella and motile cilia share a common 9 + 2 structure, in which nine peripheral microtubule doublets (MTDs) surround a central-pair of microtubules (CP), with radial spokes connecting the MTDs to the CP. The radial spoke is a multi-protein complex that works as a mechanochemical transducer between the CP and the MTDs. The radial spoke contributes to the regulation of the activity of dynein motors, and thus to flagellar motility. PMID: 22754630 provides a good review of radial spokes. [provided by RefSeq, Jul 2017]
Expression
Restricted expression toward testis (RPKM 17.8) See more
Orthologs
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Genomic context

See RSPH10B2 in Genome Data Viewer
Location:
7p22.1
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6752100..6798765)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6873233..6917958)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6793734..6838396)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family member E20, pseudogene Neighboring gene PMS2 C-terminal like pseudogene Neighboring gene CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated Neighboring gene Sharpr-MPRA regulatory region 9278

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36092, FLJ54347, FLJ95901

General protein information

Preferred Names
radial spoke head 10 homolog B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099697.2NP_001093167.1  radial spoke head 10 homolog B2

    See identical proteins and their annotated locations for NP_001093167.1

    Status: VALIDATED

    Source sequence(s)
    AC073343, AC079882
    Consensus CDS
    CCDS43552.1
    UniProtKB/Swiss-Prot
    B2RC85
    Related
    ENSP00000386102.1, ENST00000404077.6
    Conserved Domains (1) summary
    PLN03185
    Location:106320
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6752100..6798765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446908.2XP_024302676.1  radial spoke head 10 homolog B2 isoform X8

    Conserved Domains (2) summary
    PLN03185
    Location:128318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86162
    COG4642; Uncharacterized conserved protein [Function unknown]
  2. XM_024446904.2XP_024302672.1  radial spoke head 10 homolog B2 isoform X3

    Conserved Domains (2) summary
    PLN03185
    Location:128318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86162
    COG4642; Uncharacterized conserved protein [Function unknown]
  3. XM_024446906.2XP_024302674.1  radial spoke head 10 homolog B2 isoform X5

    Conserved Domains (2) summary
    PLN03185
    Location:128318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86162
    COG4642; Uncharacterized conserved protein [Function unknown]
  4. XM_024446905.2XP_024302673.1  radial spoke head 10 homolog B2 isoform X4

    Conserved Domains (1) summary
    PLN03185
    Location:106320
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
  5. XM_047420783.1XP_047276739.1  radial spoke head 10 homolog B2 isoform X4

  6. XM_047420782.1XP_047276738.1  radial spoke head 10 homolog B2 isoform X1

  7. XM_024446903.2XP_024302671.1  radial spoke head 10 homolog B2 isoform X2

    Conserved Domains (1) summary
    PLN03185
    Location:106320
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
  8. XM_024446902.2XP_024302670.1  radial spoke head 10 homolog B2 isoform X1

    Conserved Domains (2) summary
    PLN03185
    Location:128318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86162
    COG4642; Uncharacterized conserved protein [Function unknown]
  9. XM_006715766.3XP_006715829.1  radial spoke head 10 homolog B2 isoform X1

    See identical proteins and their annotated locations for XP_006715829.1

    Conserved Domains (2) summary
    PLN03185
    Location:128318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86162
    COG4642; Uncharacterized conserved protein [Function unknown]
  10. XM_011515493.2XP_011513795.1  radial spoke head 10 homolog B2 isoform X1

    See identical proteins and their annotated locations for XP_011513795.1

    Conserved Domains (2) summary
    PLN03185
    Location:128318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86162
    COG4642; Uncharacterized conserved protein [Function unknown]
  11. XM_011515491.2XP_011513793.1  radial spoke head 10 homolog B2 isoform X1

    See identical proteins and their annotated locations for XP_011513793.1

    Conserved Domains (2) summary
    PLN03185
    Location:128318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86162
    COG4642; Uncharacterized conserved protein [Function unknown]
  12. XM_047420784.1XP_047276740.1  radial spoke head 10 homolog B2 isoform X7

  13. XM_005249833.5XP_005249890.1  radial spoke head 10 homolog B2 isoform X6

    Conserved Domains (1) summary
    PLN03185
    Location:11126
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6873233..6917958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)