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Ttc19 tetratricopeptide repeat domain 19 [ Mus musculus (house mouse) ]

Gene ID: 72795, updated on 30-Dec-2022

Summary

Official Symbol
Ttc19provided by MGI
Official Full Name
tetratricopeptide repeat domain 19provided by MGI
Primary source
MGI:MGI:1920045
See related
Ensembl:ENSMUSG00000042298 AllianceGenome:MGI:1920045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010204O13Rik; 2810460C24Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in dorsal root ganglion; facial ganglion; glossopharyngeal ganglion; head; and trigeminal ganglion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 2. Orthologous to human TTC19 (tetratricopeptide repeat domain 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 13.5), frontal lobe adult (RPKM 13.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ttc19 in Genome Data Viewer
Location:
11; 11 B2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62172256..62208611)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62281429..62331879)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene adenosine A2b receptor Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene anaphase-promoting complex subunit 15 pseudogene Neighboring gene nuclear receptor co-repressor 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene centromere protein V

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 19, mitochondrial
Names
TPR repeat protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028360.3NP_082636.3  tetratricopeptide repeat protein 19, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_082636.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL596110
    Consensus CDS
    CCDS36177.1
    UniProtKB/Swiss-Prot
    Q8CC21, Q9CYS5
    UniProtKB/TrEMBL
    Q9D857
    Related
    ENSMUSP00000054367.7, ENSMUST00000050646.13
    Conserved Domains (2) summary
    sd00006
    Location:220255
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:217301
    TPR_12; Tetratricopeptide repeat
  2. NM_029704.3NP_083980.2  tetratricopeptide repeat protein 19, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) is shorter and lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AL596110
    Consensus CDS
    CCDS48817.1
    UniProtKB/Swiss-Prot
    Q8CC21
    UniProtKB/TrEMBL
    Q9D857
    Related
    ENSMUSP00000098636.5, ENSMUST00000101075.11
    Conserved Domains (2) summary
    sd00006
    Location:207242
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:204288
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62172256..62208611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534321.5XP_006534384.1  tetratricopeptide repeat protein 19, mitochondrial isoform X1

    Conserved Domains (2) summary
    sd00006
    Location:220255
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:218301
    TPR_12; Tetratricopeptide repeat
  2. XM_036157019.1XP_036012912.1  tetratricopeptide repeat protein 19, mitochondrial isoform X2

    Conserved Domains (2) summary
    sd00006
    Location:207242
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:205288
    TPR_12; Tetratricopeptide repeat

RNA

  1. XR_001780061.3 RNA Sequence

  2. XR_001780062.3 RNA Sequence

  3. XR_388537.5 RNA Sequence

  4. XR_003949515.2 RNA Sequence

  5. XR_001780063.3 RNA Sequence