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TLCD2 TLC domain containing 2 [ Homo sapiens (human) ]

Gene ID: 727910, updated on 12-Oct-2019

Summary

Official Symbol
TLCD2provided by HGNC
Official Full Name
TLC domain containing 2provided by HGNC
Primary source
HGNC:HGNC:33522
See related
Ensembl:ENSG00000185561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in fat (RPKM 9.2), colon (RPKM 5.9) and 17 other tissues See more
Orthologs

Genomic context

See TLCD2 in Genome Data Viewer
Location:
17p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (1702816..1710377, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1606084..1613662, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein Neighboring gene pre-mRNA processing factor 8 Neighboring gene MIR22 host gene Neighboring gene microRNA 22 Neighboring gene WD repeat domain 81

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane lipid distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TLC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164407.2NP_001157879.1  TLC domain-containing protein 2

    See identical proteins and their annotated locations for NP_001157879.1

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Consensus CDS
    CCDS45567.1
    UniProtKB/Swiss-Prot
    A6NGC4
    Related
    ENSP00000331965.6, ENST00000330676.8
    Conserved Domains (1) summary
    smart00724
    Location:34223
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    1702816..1710377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187611.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    132844..140405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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