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RGPD8 RANBP2 like and GRIP domain containing 8 [ Homo sapiens (human) ]

Gene ID: 727851, updated on 24-Nov-2020

Summary

Official Symbol
RGPD8provided by HGNC
Official Full Name
RANBP2 like and GRIP domain containing 8provided by HGNC
Primary source
HGNC:HGNC:9849
See related
Ensembl:ENSG00000169629 MIM:602752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP8; RANBP2L1; RanBP2alpha
Expression
Broad expression in testis (RPKM 26.7), brain (RPKM 9.2) and 25 other tissues See more

Genomic context

See RGPD8 in Genome Data Viewer
Location:
2q14.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (112368369..112433645, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113125946..113191222, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 6 Neighboring gene zinc finger CCCH-type containing 6 Neighboring gene axin 2 pseudogene Neighboring gene tubulin tyrosine ligase Neighboring gene uncharacterized LOC105373562 Neighboring gene RNA polymerase I subunit B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RANBP2-like and GRIP domain containing 8 (RGPD8) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
RANBP2-like and GRIP domain-containing protein 8
Names
RAN binding protein 2-like 1
ran-binding protein 2-like 3
ranBP2-like 3
ranBP2L3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164463.1NP_001157935.1  RANBP2-like and GRIP domain-containing protein 8

    See identical proteins and their annotated locations for NP_001157935.1

    Status: VALIDATED

    Source sequence(s)
    AC112246, AC115115
    Consensus CDS
    CCDS46394.1
    UniProtKB/Swiss-Prot
    O14715
    Related
    ENSP00000306637.3, ENST00000302558.8
    Conserved Domains (8) summary
    COG5171
    Location:9751167
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10511167
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13481464
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:17071749
    GRIP; GRIP domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
    pfam16704
    Location:16411705
    Rab_bind; Rab binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    112368369..112433645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453101.1XP_024308869.1  RANBP2-like and GRIP domain-containing protein 8 isoform X1

    Related
    ENSP00000386511.1, ENST00000409750.5
    Conserved Domains (7) summary
    COG0457
    Location:4100
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13177
    Location:10251141
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13221438
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:3363
    TPR; TPR repeat [structural motif]
    pfam16704
    Location:16151679
    Rab_bind; Rab binding domain
    pfam00515
    Location:3466
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:16801723
    GRIP; GRIP domain
  2. XM_005263747.5XP_005263804.1  RANBP2-like and GRIP domain-containing protein 8 isoform X4

    Conserved Domains (6) summary
    COG5171
    Location:9751167
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10511167
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13481464
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  3. XM_011511733.2XP_011510035.1  RANBP2-like and GRIP domain-containing protein 8 isoform X2

    Conserved Domains (6) summary
    COG5171
    Location:9751167
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10511167
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13481464
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  4. XM_017004825.1XP_016860314.1  RANBP2-like and GRIP domain-containing protein 8 isoform X3

  5. XM_017004826.2XP_016860315.1  RANBP2-like and GRIP domain-containing protein 8 isoform X5

    UniProtKB/TrEMBL
    F8W705
    Related
    ENSP00000327486.5, ENST00000330575.9
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