Format

Send to:

Choose Destination

Rspo3 R-spondin 3 [ Mus musculus (house mouse) ]

Gene ID: 72780, updated on 10-Oct-2019

Summary

Official Symbol
Rspo3provided by MGI
Official Full Name
R-spondin 3provided by MGI
Primary source
MGI:MGI:1920030
See related
Ensembl:ENSMUSG00000019880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thsd2; AW742308; Cristin1; 2810459H04Rik
Expression
Broad expression in adrenal adult (RPKM 11.5), ovary adult (RPKM 5.6) and 20 other tissues See more
Orthologs

Genomic context

See Rspo3 in Genome Data Viewer
Location:
10; 10 A4
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (29453106..29535867, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (29172912..29255673, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene predicted gene, 18903 Neighboring gene predicted gene, 46197 Neighboring gene predicted gene, 46219 Neighboring gene Rpl12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC118442

Gene Ontology Provided by MGI

Function Evidence Code Pubs
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in labyrinthine layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
R-spondin-3
Names
R-spondin 3 homolog
cabriolet
cristin 1
cysteine-rich and single thrombospondin domain-containing protein 1
nucleopondin
roof plate-specific spondin-3
thrombospondin, type I, domain 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028351.3NP_082627.3  R-spondin-3 precursor

    See identical proteins and their annotated locations for NP_082627.3

    Status: VALIDATED

    Source sequence(s)
    AK133916, BC103794
    Consensus CDS
    CCDS23761.1
    UniProtKB/Swiss-Prot
    Q2TJ95
    Related
    ENSMUSP00000090287.3, ENSMUST00000092623.4
    Conserved Domains (3) summary
    smart00209
    Location:151202
    TSP1; Thrombospondin type 1 repeats
    cd00064
    Location:97143
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam15913
    Location:42144
    Furin-like_2; Furin-like repeat, cysteine-rich

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    29453106..29535867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center