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Rint1 RAD50 interactor 1 [ Mus musculus (house mouse) ]

Gene ID: 72772, updated on 8-Feb-2024

Summary

Official Symbol
Rint1provided by MGI
Official Full Name
RAD50 interactor 1provided by MGI
Primary source
MGI:MGI:1916233
See related
Ensembl:ENSMUSG00000028999 AllianceGenome:MGI:1916233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rint-1; 1500019C06Rik; 2810450M21Rik
Summary
Predicted to be involved in mitotic G2 DNA damage checkpoint signaling; regulation of ER to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.8), limb E14.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
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Genomic context

See Rint1 in Genome Data Viewer
Location:
5 A3; 5 10.45 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (23992700..24028582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (23787698..23823584)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI506816 Neighboring gene STARR-positive B cell enhancer ABC_E8818 Neighboring gene STARR-positive B cell enhancer ABC_E3564 Neighboring gene predicted gene, 50451 Neighboring gene pseudouridylate synthase 7 Neighboring gene STARR-seq mESC enhancer starr_12621 Neighboring gene STARR-positive B cell enhancer ABC_E4745 Neighboring gene RIKEN cDNA 4933427G23 gene Neighboring gene predicted gene, 22054

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC183656

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of Dsl1/NZR complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Dsl1/NZR complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RAD50-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310467.1NP_001297396.1  RAD50-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001297396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK005284, AK028707, BC065059
    Consensus CDS
    CCDS80220.1
    UniProtKB/TrEMBL
    B2RWX4
    Related
    ENSMUSP00000110766.3, ENSMUST00000115113.3
    Conserved Domains (1) summary
    pfam04437
    Location:246726
    RINT1_TIP1; RINT-1 / TIP-1 family
  2. NM_177323.4NP_796297.2  RAD50-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_796297.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK005284, AK135334, BC065059
    Consensus CDS
    CCDS39025.1
    UniProtKB/Swiss-Prot
    Q3UXS1, Q6P1I2, Q8BZ36, Q8C193
    UniProtKB/TrEMBL
    B2RWX4
    Related
    ENSMUSP00000030852.7, ENSMUST00000030852.13
    Conserved Domains (1) summary
    pfam04437
    Location:304784
    RINT1_TIP1; RINT-1 / TIP-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    23992700..24028582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165534.1XP_036021427.1  RAD50-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    B2RWX4
    Conserved Domains (1) summary
    pfam04437
    Location:168648
    RINT1_TIP1; RINT-1 / TIP-1 family

RNA

  1. XR_001784750.2 RNA Sequence