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CASC8 cancer susceptibility 8 [ Homo sapiens (human) ]

Gene ID: 727677, updated on 20-Dec-2021

Summary

Official Symbol
CASC8provided by HGNC
Official Full Name
cancer susceptibility 8provided by HGNC
Primary source
HGNC:HGNC:45129
See related
Ensembl:ENSG00000246228 MIM:617701
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CARLO1; CARLo-1; LINC00860
Expression
Low expression observed in reference dataset See more
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Genomic context

See CASC8 in Genome Data Viewer
Location:
8q24.21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (127289676..127482139, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128301921..128494384, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CASC19-CCAT1 intergenic CAGE-defined high expression enhancer Neighboring gene CCAT1 intron CAGE-defined B cell enhancer Neighboring gene colon cancer associated transcript 1 Neighboring gene cancer susceptibility 21 Neighboring gene POU class 5 homeobox 1B Neighboring gene colon cancer associated transcript 2 Neighboring gene uncharacterized LOC105375754 Neighboring gene origin of replication upstream of MYC Neighboring gene cancer susceptibility 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
EBI GWAS Catalog
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
EBI GWAS Catalog
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
EBI GWAS Catalog
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
EBI GWAS Catalog

General gene information

Markers

Other Names

  • cancer susceptibility 8 (non-protein coding)
  • cancer susceptibility candidate 8 (non-protein coding)
  • long intergenic non-protein coding RNA 860

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024393.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC016883
    Related
    ENST00000502056.1
  2. NR_117100.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC016883, AC018714
    Related
    ENST00000502082.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    127289676..127482139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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