Tonsl tonsoku-like, DNA repair protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tonslprovided by MGI
Official Full Name: tonsoku-like, DNA repair proteinprovided by MGI
Primary source: MGI:MGI:1919999
See related: Ensembl:ENSMUSG00000059323 AllianceGenome:MGI:1919999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nfkbil2; 2810439M11Rik
Summary: Predicted to enable histone binding activity and histone reader activity. Predicted to be involved in double-strand break repair via homologous recombination; protein localization to chromatin; and replication fork processing. Predicted to be located in nuclear body. Predicted to be part of DNA replication factor A complex; FACT complex; and MCM complex. Predicted to be active in nuclear replication fork and site of double-strand break. Is expressed in several structures, including brain ventricular layer; cerebellum; foregut; sensory organ; and tooth. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Orthologous to human TONSL (tonsoku like, DNA repair protein). [provided by Alliance of Genome Resources, Mar 2025]
Expression: Ubiquitous expression in duodenum adult (RPKM 12.6), large intestine adult (RPKM 12.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 36.18 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76510437..76524129, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76626237..76639929, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of DNA replication factor A complex	ISO Inferred from Sequence Orthology more info
part_of DNA replication factor A complex	ISS Inferred from Sequence or Structural Similarity more info
part_of FACT complex	ISO Inferred from Sequence Orthology more info
part_of FACT complex	ISS Inferred from Sequence or Structural Similarity more info
part_of MCM complex	ISO Inferred from Sequence Orthology more info
part_of MCM complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nuclear replication fork	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tonsoku-like protein

Names: I-kappa-B-related protein; NF-kappa-B inhibitor-like protein 2; ikappaBR; inhibitor of kappa B-related protein; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183091.3 → NP_898914.3 tonsoku-like protein

See identical proteins and their annotated locations for NP_898914.3

Status: VALIDATED

Source sequence(s)

AK139173, BC066068

Consensus CDS

CCDS27580.2

UniProtKB/Swiss-Prot

Q6NZL6, Q8BT74, Q9ER45

UniProtKB/TrEMBL

G3UW83

Related

ENSMUSP00000129597.2, ENSMUST00000168185.8

Conserved Domains (7) summary

cd00116
Location:1055 → 1345

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00204
Location:523 → 635

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00033
Location:1061 → 1088

LRR_RI; leucine-rich repeat [structural motif]

sd00006
Location:316 → 339

TPR; TPR repeat [structural motif]

pfam12796
Location:533 → 627

Ank_2; Ankyrin repeats (3 copies)

pfam13424
Location:310 → 383

TPR_12; Tetratricopeptide repeat

sd00045
Location:528 → 559

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

76510437..76524129 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316755.2 → XP_017172244.1 tonsoku-like protein isoform X1

UniProtKB/Swiss-Prot

Q6NZL6, Q8BT74, Q9ER45

Conserved Domains (8) summary

PHA03247
Location:513 → 772

PHA03247; large tegument protein UL36; Provisional

COG0457
Location:37 → 268

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

COG0666
Location:338 → 531

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00033
Location:911 → 938

LRR_RI; leucine-rich repeat [structural motif]

sd00006
Location:166 → 189

TPR; TPR repeat [structural motif]

sd00045
Location:378 → 409

ANK; ANK repeat [structural motif]

pfam12796
Location:383 → 477

Ank_2; Ankyrin repeats (3 copies)

cl39015
Location:905 → 1195

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...