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B3gat3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) [ Mus musculus (house mouse) ]

Gene ID: 72727, updated on 26-Sep-2022

Summary

Official Symbol
B3gat3provided by MGI
Official Full Name
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)provided by MGI
Primary source
MGI:MGI:1919977
See related
Ensembl:ENSMUSG00000071649 AllianceGenome:MGI:1919977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810405M13Rik
Summary
Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity and protein phosphatase activator activity. Predicted to be involved in several processes, including chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of intracellular protein transport. Predicted to act upstream of or within dermatan sulfate proteoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi membrane. Is expressed in several structures, including cranium; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 58.2), cerebellum adult (RPKM 55.6) and 28 other tissues See more
Orthologs
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Genomic context

See B3gat3 in Genome Data Viewer
Location:
19; 19 A
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8897740..8904600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8920374..8927236)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 5 Neighboring gene alpha glucosidase 2 alpha neutral subunit Neighboring gene predicted gene, 36629 Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene metastasis-associated gene family, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Names
UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase
glcAT-I
glcUAT-I
glucuronosyltransferase I
glucuronyltransferase I
NP_077218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024256.2NP_077218.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

    See identical proteins and their annotated locations for NP_077218.1

    Status: VALIDATED

    Source sequence(s)
    BC004038
    Consensus CDS
    CCDS29558.1
    UniProtKB/Swiss-Prot
    P58158
    Related
    ENSMUSP00000093962.6, ENSMUST00000096243.7
    Conserved Domains (1) summary
    cd00218
    Location:75313
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8897740..8904600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003952823.2 RNA Sequence