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Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 [ Mus musculus (house mouse) ]

Gene ID: 72685, updated on 26-Jun-2024

Summary

Official Symbol
Dnajc6provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C6provided by MGI
Primary source
MGI:MGI:1919935
See related
Ensembl:ENSMUSG00000028528 AllianceGenome:MGI:1919935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0473; 2810027M23Rik
Summary
Predicted to enable clathrin binding activity. Involved in synaptic vesicle uncoating. Acts upstream of or within clathrin coat disassembly and regulation of clathrin-dependent endocytosis. Located in postsynaptic density. Is expressed in genital tubercle of male; gut; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 27.2), cortex adult (RPKM 25.9) and 7 other tissues See more
Orthologs
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Genomic context

See Dnajc6 in Genome Data Viewer
Location:
4 C6; 4 46.89 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101353751..101499996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101496648..101642799)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene STARR-seq mESC enhancer starr_10903 Neighboring gene ribosomal protein L9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10910 Neighboring gene adenylate kinase 4 Neighboring gene STARR-seq mESC enhancer starr_10915 Neighboring gene predicted gene, 36012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:101319917-101320026 Neighboring gene STARR-positive B cell enhancer ABC_E2698 Neighboring gene leptin receptor overlapping transcript Neighboring gene STARR-seq mESC enhancer starr_10917 Neighboring gene leptin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extrinsic component of presynaptic endocytic zone membrane EXP
Inferred from Experiment
more info
PubMed 
is_active_in extrinsic component of presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
auxilin
Names
DnaJ (Hsp40) homolog, subfamily B, member 6
DnaJ (Hsp40) homolog, subfamily C, member 6
dnaJ homolog subfamily C member 6
putative tyrosine-protein phosphatase auxilin
NP_001158055.1
NP_001158056.1
NP_001158057.1
NP_001342108.1
NP_001342109.1
NP_940804.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164583.2NP_001158055.1  auxilin isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS51238.1
    UniProtKB/Swiss-Prot
    Q80TZ3
    Related
    ENSMUSP00000102546.2, ENSMUST00000106933.2
    Conserved Domains (2) summary
    cd06257
    Location:916961
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:281419
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  2. NM_001164584.2NP_001158056.1  auxilin isoform b

    See identical proteins and their annotated locations for NP_001158056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS51237.1
    UniProtKB/Swiss-Prot
    B1B0B9, Q6P2K9, Q80TZ3, Q8C7L9
    Related
    ENSMUSP00000044251.6, ENSMUST00000038207.12
    Conserved Domains (2) summary
    cd06257
    Location:886931
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:251389
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  3. NM_001164585.2NP_001158057.1  auxilin isoform c

    See identical proteins and their annotated locations for NP_001158057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3. 4 and 6 encode the same isoform.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS18395.1
    UniProtKB/Swiss-Prot
    Q80TZ3
    Conserved Domains (3) summary
    cd06257
    Location:848893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:213351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:521752
    Atrophin-1; Atrophin-1 family
  4. NM_001355179.2NP_001342108.1  auxilin isoform d

    Status: VALIDATED

    Source sequence(s)
    AL845364, BX323551
    Conserved Domains (3) summary
    cd06257
    Location:889934
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:254392
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl25496
    Location:536821
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  5. NM_001355180.2NP_001342109.1  auxilin isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3. 4 and 6 encode the same isoform.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS18395.1
    Related
    ENSMUSP00000102542.4, ENSMUST00000106929.10
    Conserved Domains (3) summary
    cd06257
    Location:848893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:213351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:521752
    Atrophin-1; Atrophin-1 family
  6. NM_198412.3NP_940804.1  auxilin isoform c

    See identical proteins and their annotated locations for NP_940804.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a segment of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 6 encode the same isoform.
    Source sequence(s)
    AL845364, BX323551
    Consensus CDS
    CCDS18395.1
    UniProtKB/Swiss-Prot
    Q80TZ3
    Related
    ENSMUSP00000102543.2, ENSMUST00000106930.8
    Conserved Domains (3) summary
    cd06257
    Location:848893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:213351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:521752
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101353751..101499996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)