U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Mus musculus (house mouse) ]

Gene ID: 72662, updated on 9-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Dis3provided by MGI
Official Full Name
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by MGI
Primary source
MGI:MGI:1919912
See related
Ensembl:ENSMUSG00000033166 AllianceGenome:MGI:1919912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810028N01Rik
Summary
Predicted to enable 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in CUT catabolic process and rRNA catabolic process. Predicted to act upstream of or within rRNA processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in renal cortex; telencephalon ventricular layer; and thymus primordium. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.1), limb E14.5 (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dis3 in Genome Data Viewer
Location:
14; 14 E2.2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99314070..99337217, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99076634..99099780, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm829 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene bora, aurora kinase A activator Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene Kruppel-like factor 5 Neighboring gene predicted gene, 22984

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Isolation of murine and human homologues of the fission-yeast dis3+ gene encoding a mitotic-control protein and its overexpression in cancer cells with progressive phenotype. Lim J, et al. Cancer Res, 1997 Mar 1. PMID 9041195
  2. The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA. Segalla S, et al. Nucleic Acids Res, 2015 May 26. PMID 25925570, Free PMC Article
  3. MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3. Zhang T, et al. Kaohsiung J Med Sci, 2022 Jun. PMID 35394705
  4. Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells. Laffleur B, et al. Nat Genet, 2021 Feb. PMID 33526923, Free PMC Article
  5. RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation. Wu D, et al. Cell Rep, 2023 Jan 30. PMID 36724075

See all (30) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3.
    Title: MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3.
  2. Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.
    Title: Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.
  3. The study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation.
    Title: The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CUT catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear exosome (RNase complex) NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
exosome complex exonuclease RRP44
Names
DIS3 mitotic control homolog
protein DIS3 homolog
ribosomal RNA-processing protein 44

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360050.1 → NP_001346979.1  exosome complex exonuclease RRP44 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154843, AK032091, AK038313, CN705423
    Conserved Domains (2) summary
    COG0557
    Location:101 → 836
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:1 → 103
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  2. NM_001360051.1 → NP_001346980.1  exosome complex exonuclease RRP44 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154843, AK032091, AK038313, CN705423
    Conserved Domains (1) summary
    COG0557
    Location:2 → 741
    VacB; Exoribonuclease R [Transcription]

  3. NM_028315.2 → NP_082591.2  exosome complex exonuclease RRP44 isoform 1

    See identical proteins and their annotated locations for NP_082591.2

    Status: VALIDATED

    Source sequence(s)
    AC154843, AK012840, AK032091, CJ176790, CN705423
    Consensus CDS
    CCDS49555.1
    UniProtKB/Swiss-Prot
    Q8C074, Q9CSH3
    Related
    ENSMUSP00000041906.10, ENSMUST00000042471.11
    Conserved Domains (3) summary
    cd09862
    Location:9 → 197
    PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    COG0557
    Location:195 → 930
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:467 → 795
    RNB; RNB domain

RNA

  1. NR_153390.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843, AK012840, AK032091, AK038313, CN705423
    Related
    ENSMUST00000228643.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    99314070..99337217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519602.5 → XP_006519665.1  exosome complex exonuclease RRP44 isoform X3

    Conserved Domains (2) summary
    COG0557
    Location:165 → 900
    VacB; Exoribonuclease R [Transcription]
    cd09862
    Location:9 → 167
    PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

  2. XM_030248047.1 → XP_030103907.1  exosome complex exonuclease RRP44 isoform X1

    Conserved Domains (1) summary
    COG0557
    Location:2 → 741
    VacB; Exoribonuclease R [Transcription]

  3. XM_017316212.3 → XP_017171701.1  exosome complex exonuclease RRP44 isoform X2

    Conserved Domains (2) summary
    cd09862
    Location:9 → 197
    PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    cl39058
    Location:195 → 545
    RNB; RNB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CSH3.4 GenPept UniProtKB/Swiss-Prot:Q9CSH3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous