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Usp13 ubiquitin specific peptidase 13 (isopeptidase T-3) [ Mus musculus (house mouse) ]

Gene ID: 72607, updated on 12-May-2024

Summary

Official Symbol
Usp13provided by MGI
Official Full Name
ubiquitin specific peptidase 13 (isopeptidase T-3)provided by MGI
Primary source
MGI:MGI:1919857
See related
Ensembl:ENSMUSG00000056900 AllianceGenome:MGI:1919857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ISOT3; IsoT-3; 2700071E21Rik
Summary
Predicted to enable several functions, including BAT3 complex binding activity; chaperone binding activity; and cysteine-type peptidase activity. Predicted to be involved in several processes, including proteolysis; regulation of cellular catabolic process; and regulation of transcription, DNA-templated. Predicted to act upstream of or within protein K29-linked deubiquitination; protein K6-linked deubiquitination; and protein stabilization. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 18.6), frontal lobe adult (RPKM 2.9) and 10 other tissues See more
Orthologs
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Genomic context

See Usp13 in Genome Data Viewer
Location:
3 A3; 3 15.88 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32870432..32992224)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32816283..32938075)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:32635708-32635977 Neighboring gene STARR-seq mESC enhancer starr_07351 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene NADH:ubiquinone oxidoreductase subunit B5 Neighboring gene peroxisomal biogenesis factor 5-like Neighboring gene RIKEN cDNA 4930419G24 gene Neighboring gene predicted gene, 23214 Neighboring gene STARR-seq mESC enhancer starr_07354

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107670

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BAT3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 13
Names
deubiquitinating enzyme 13
ubiquitin specific protease 13 (isopeptidase T-3)
ubiquitin thioesterase 13
ubiquitin-specific-processing protease 13
NP_001013042.1
XP_030108701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013024.2NP_001013042.1  ubiquitin carboxyl-terminal hydrolase 13

    See identical proteins and their annotated locations for NP_001013042.1

    Status: PROVISIONAL

    Source sequence(s)
    AC111140
    Consensus CDS
    CCDS17301.1
    UniProtKB/Swiss-Prot
    D3YYG7, Q5BKP2
    UniProtKB/TrEMBL
    J3QSN2
    Related
    ENSMUSP00000072155.6, ENSMUST00000072312.12
    Conserved Domains (2) summary
    COG5207
    Location:28856
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02658
    Location:335854
    Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    32870432..32992224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252841.1XP_030108701.1  ubiquitin carboxyl-terminal hydrolase 13 isoform X1

    Conserved Domains (3) summary
    cd02658
    Location:86605
    Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14384
    Location:401449
    UBA1_UBP13; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase 13 (UBP13)
    cd14386
    Location:474515
    UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)

RNA

  1. XR_003954401.2 RNA Sequence