Usp13 ubiquitin specific peptidase 13 (isopeptidase T-3) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp13provided by MGI
Official Full Name: ubiquitin specific peptidase 13 (isopeptidase T-3)provided by MGI
Primary source: MGI:MGI:1919857
See related: Ensembl:ENSMUSG00000056900 AllianceGenome:MGI:1919857
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ISOT3; IsoT-3; 2700071E21Rik
Summary: Predicted to enable several functions, including BAT3 complex binding activity; chaperone binding activity; and cysteine-type peptidase activity. Predicted to be involved in several processes, including proteolysis; regulation of cellular catabolic process; and regulation of transcription, DNA-templated. Predicted to act upstream of or within protein K29-linked deubiquitination; protein K6-linked deubiquitination; and protein stabilization. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 18.6), frontal lobe adult (RPKM 2.9) and 10 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3; 3 A3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (32870432..32992224)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (32816283..32938075)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP13 Deficiency Impairs Autophagy and Facilitates Age-related Lung Fibrosis.
Title: USP13 Deficiency Impairs Autophagy and Facilitates Age-related Lung Fibrosis.
Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice.
Title: Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice.
USP13-mediated IRAK4 deubiquitination disrupts the pathological symptoms of lipopolysaccharides-induced sepsis.
Title: USP13-mediated IRAK4 deubiquitination disrupts the pathological symptoms of lipopolysaccharides-induced sepsis.
USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model.
Title: USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model.
Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naive and primed pluripotent stem cells.
Title: Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.
Lipopolysaccharide reduces USP13 stability through c-Jun N-terminal kinase activation in Kupffer cells.
Title: Lipopolysaccharide reduces USP13 stability through c-Jun N-terminal kinase activation in Kupffer cells.
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
Title: Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
Stabilization of IL-1R8/Sigirr by USP13 describes a novel anti-inflammatory pathway in diseases that could provide a new strategy to modulate immune activation
Title: The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
Usp13 deconjugates polyubiquitin chains from STING and prevents the recruitment of Tbk1 to the signalling complex, thereby negatively regulating cellular antiviral responses.
Title: USP13 negatively regulates antiviral responses by deubiquitinating STING.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Homologs of the Usp13 gene: The Usp13 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 489 organisms have orthologs with human gene Usp13
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BAT3 complex binding	ISO Inferred from Sequence Orthology more info
enables K48-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of unfolded protein involved in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein K29-linked deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein K6-linked deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ubiquitin carboxyl-terminal hydrolase 13

Names: deubiquitinating enzyme 13; ubiquitin specific protease 13 (isopeptidase T-3); ubiquitin thioesterase 13; ubiquitin-specific-processing protease 13

NP_001013042.1

EC 3.4.19.12

XP_030108701.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013024.2 → NP_001013042.1 ubiquitin carboxyl-terminal hydrolase 13

See identical proteins and their annotated locations for NP_001013042.1

Status: PROVISIONAL

Source sequence(s)

AC111140

Consensus CDS

CCDS17301.1

UniProtKB/Swiss-Prot

D3YYG7, Q5BKP2

Related

ENSMUSP00000072155.6, ENSMUST00000072312.12

Conserved Domains (2) summary

COG5207
Location:28 → 856

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd02658
Location:335 → 854

Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

32870432..32992224

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252841.1 → XP_030108701.1 ubiquitin carboxyl-terminal hydrolase 13 isoform X1

Conserved Domains (3) summary

cd02658
Location:86 → 605

Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cd14384
Location:401 → 449

UBA1_UBP13; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase 13 (UBP13)

cd14386
Location:474 → 515

UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)