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Lypd1 Ly6/Plaur domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 72585, updated on 11-Sep-2019

Summary

Official Symbol
Lypd1provided by MGI
Official Full Name
Ly6/Plaur domain containing 1provided by MGI
Primary source
MGI:MGI:1919835
See related
Ensembl:ENSMUSG00000026344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lynx2; Lypdc1; AI853408; 2700050C12Rik; C530008O16Rik
Expression
Broad expression in CNS E18 (RPKM 5.8), cortex adult (RPKM 5.8) and 24 other tissues See more
Orthologs

Genomic context

See Lypd1 in Genome Data Viewer
Location:
1; 1 E3
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (125867622..125913175, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (127768616..127808791, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene G protein-coupled receptor 39 Neighboring gene predicted gene, 41943 Neighboring gene NCK-associated protein 5 Neighboring gene predicted gene, 35562 Neighboring gene uncharacterized LOC102639337

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylcholine receptor inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine receptor inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, cholinergic IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 1
Names
ly-6/neurotoxin-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311089.1NP_001298018.1  ly6/PLAUR domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001298018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC153655, AK082941, BQ175060
    Consensus CDS
    CCDS78672.1
    UniProtKB/Swiss-Prot
    Q8BLC3
    UniProtKB/TrEMBL
    E0CXP0
    Related
    ENSMUSP00000027582.4, ENSMUST00000027582.9
  2. NM_001311090.1NP_001298019.1  ly6/PLAUR domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001298019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC153655, AK012406, BQ175060, BY073265
    Consensus CDS
    CCDS78672.1
    UniProtKB/Swiss-Prot
    Q8BLC3
    UniProtKB/TrEMBL
    E0CXP0
    Related
    ENSMUSP00000125158.1, ENSMUST00000162899.7
  3. NM_145100.4NP_659568.2  ly6/PLAUR domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_659568.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC153655, AK045592, BQ175060
    Consensus CDS
    CCDS15243.1
    UniProtKB/Swiss-Prot
    Q8BLC3
    Related
    ENSMUSP00000125149.1, ENSMUST00000159417.1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    125867622..125913175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529885.4XP_006529948.3  ly6/PLAUR domain-containing protein 1 isoform X2

  2. XM_011248088.3XP_011246390.2  ly6/PLAUR domain-containing protein 1 isoform X1

  3. XM_017312443.2XP_017167932.1  ly6/PLAUR domain-containing protein 1 isoform X3

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