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Zup1 zinc finger containing ubiquitin peptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 72580, updated on 5-Jan-2023

Summary

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Official Symbol
Zup1provided by MGI
Official Full Name
zinc finger containing ubiquitin peptidase 1provided by MGI
Primary source
MGI:MGI:1919830
See related
Ensembl:ENSMUSG00000039531 AllianceGenome:MGI:1919830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DUB; Zufsp; 2700019D07Rik
Summary
Predicted to enable metal ion binding activity and thiol-dependent deubiquitinase. Predicted to be involved in regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZUP1 (zinc finger containing ubiquitin peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.0), CNS E11.5 (RPKM 3.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Zup1 in Genome Data Viewer
Location:
10; 10 B1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (33795138..33827316, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (33919142..33951294, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 3A, member 1 Neighboring gene radial spoke head 4 homolog A (Chlamydomonas) Neighboring gene predicted gene, 48018 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA A830082N09 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107205

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger-containing ubiquitin peptidase 1
Names
lys-63-specific deubiquitinase ZUFSP
ubiquitin carboxyl-terminal hydrolase ZUFSP
zinc finger with UFM1-specific peptidase domain protein
NP_001346384.1
NP_001346385.1
NP_082563.1
XP_006512931.1
XP_006512932.1
XP_006512933.1
XP_030101163.1
XP_036011935.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359455.1 → NP_001346384.1  zinc finger-containing ubiquitin peptidase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK077304, AK077730, AV316666
    Consensus CDS
    CCDS87987.1
    UniProtKB/Swiss-Prot
    Q9CSP5
    Related
    ENSMUSP00000151811.2, ENSMUST00000218055.2
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 550
    Peptidase_C78; Peptidase family C78

  2. NM_001359456.1 → NP_001346385.1  zinc finger-containing ubiquitin peptidase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK052071, AK077304, AV316666
    Related
    ENSMUSP00000151662.2, ENSMUST00000218880.2
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 535
    Peptidase_C78; Peptidase family C78

  3. NM_028287.3 → NP_082563.1  zinc finger-containing ubiquitin peptidase 1 isoform 2

    See identical proteins and their annotated locations for NP_082563.1

    Status: VALIDATED

    Source sequence(s)
    AK046191, AK077304, AK164710
    Consensus CDS
    CCDS23772.1
    UniProtKB/Swiss-Prot
    Q3T9Z9
    Related
    ENSMUSP00000037121.5, ENSMUST00000048222.6
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 550
    Peptidase_C78; Peptidase family C78

RNA

  1. NR_153113.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK077304, AK077730, AV316666, BC067065
    Related
    ENSMUST00000218275.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    33795138..33827316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156042.1 → XP_036011935.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9CSP5
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 550
    Peptidase_C78; Peptidase family C78

  2. XM_030245303.2 → XP_030101163.1  zinc finger-containing ubiquitin peptidase 1 isoform X2

    Conserved Domains (1) summary
    pfam07910
    Location:140 → 355
    Peptidase_C78; Peptidase family C78

  3. XM_006512868.5 → XP_006512931.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006512931.1

    UniProtKB/Swiss-Prot
    Q3T9Z9, Q9CSP5
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 550
    Peptidase_C78; Peptidase family C78

  4. XM_006512870.5 → XP_006512933.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006512933.1

    UniProtKB/Swiss-Prot
    Q3T9Z9, Q9CSP5
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 550
    Peptidase_C78; Peptidase family C78

  5. XM_006512869.5 → XP_006512932.1  zinc finger-containing ubiquitin peptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006512932.1

    UniProtKB/Swiss-Prot
    Q3T9Z9, Q9CSP5
    Conserved Domains (1) summary
    pfam07910
    Location:335 → 550
    Peptidase_C78; Peptidase family C78
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3T9Z9.2 GenPept UniProtKB/Swiss-Prot:Q3T9Z9

Gene LinkOut

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