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Bclaf1 BCL2-associated transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 72567, updated on 5-Mar-2024

Summary

Official Symbol
Bclaf1provided by MGI
Official Full Name
BCL2-associated transcription factor 1provided by MGI
Primary source
MGI:MGI:1917580
See related
Ensembl:ENSMUSG00000037608 AllianceGenome:MGI:1917580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Btf; mKIAA0164; 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik
Summary
Predicted to enable DNA binding activity and transcription coregulator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nuclear speck. Predicted to be part of mediator complex. Is expressed in central nervous system; genitourinary system; retina; submandibular gland; and trachea. Orthologous to human BCLAF1 (BCL2 associated transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.7), CNS E14 (RPKM 17.4) and 24 other tissues See more
Orthologs
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Genomic context

See Bclaf1 in Genome Data Viewer
Location:
10 A3; 10 9.75 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20187897..20218390)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20310512..20342644)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30285 Neighboring gene STARR-seq mESC enhancer starr_25961 Neighboring gene microRNA 6413 Neighboring gene STARR-positive B cell enhancer ABC_E6822 Neighboring gene mitochondrial fission regulator 2 Neighboring gene 60S ribosomal protein L12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0164, MGC30519, MGC58035

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bcl-2-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025392.1NP_001020563.1  bcl-2-associated transcription factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001020563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC029682, BC034300, BY071148, CAAA01031508
    Consensus CDS
    CCDS35858.1
    UniProtKB/Swiss-Prot
    Q8BNZ0, Q8C2E9, Q8K019, Q9CSW5
    UniProtKB/TrEMBL
    Q3UDL9
    Related
    ENSMUSP00000043583.6, ENSMUST00000043881.12
    Conserved Domains (2) summary
    pfam15440
    Location:157744
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
    cl09653
    Location:826891
    Btz; CASC3/Barentsz eIF4AIII binding
  2. NM_001025393.1NP_001020564.1  bcl-2-associated transcription factor 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform 3 lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC086624, BY071148, CAAA01031508, CK637794, CN530237
    Consensus CDS
    CCDS23721.1
    UniProtKB/TrEMBL
    F8WI22, Q3UDL9
    Related
    ENSMUSP00000090349.4, ENSMUST00000092678.10
    Conserved Domains (1) summary
    pfam15440
    Location:157744
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  3. NM_153787.2NP_722482.1  bcl-2-associated transcription factor 1 isoform 2

    See identical proteins and their annotated locations for NP_722482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 6-nt segment in the CDS, as compared to variant 1. The encoded isoform 2 lacks 2 internal aa, as compared to isoform 1.
    Source sequence(s)
    BC034300, BY071148, CAAA01031508
    Consensus CDS
    CCDS78798.1
    UniProtKB/TrEMBL
    Q3UDL9
    Related
    ENSMUSP00000140623.2, ENSMUST00000185800.7
    Conserved Domains (2) summary
    pfam15440
    Location:155742
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
    cl09653
    Location:824889
    Btz; CASC3/Barentsz eIF4AIII binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    20187897..20218390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512865.5XP_006512928.1  bcl-2-associated transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    Q3UDL9
    Conserved Domains (1) summary
    pfam15440
    Location:155744
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  2. XM_011243207.4XP_011241509.1  bcl-2-associated transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A087WQA0, Q3TSZ0
    Related
    ENSMUSP00000140101.2, ENSMUST00000186100.7
    Conserved Domains (1) summary
    pfam15440
    Location:157739
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RNA

  1. XR_004936284.1 RNA Sequence

  2. XR_004936287.1 RNA Sequence

  3. XR_004936289.1 RNA Sequence

  4. XR_004936286.1 RNA Sequence

  5. XR_004936288.1 RNA Sequence

  6. XR_004936285.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025394.1: Suppressed sequence

    Description
    NM_001025394.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.