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Mvb12b multivesicular body subunit 12B [ Mus musculus (house mouse) ]

Gene ID: 72543, updated on 5-Mar-2024

Summary

Official Symbol
Mvb12bprovided by MGI
Official Full Name
multivesicular body subunit 12Bprovided by MGI
Primary source
MGI:MGI:1919793
See related
Ensembl:ENSMUSG00000038740 AllianceGenome:MGI:1919793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam125b; 2610200O14Rik; 2610528K11Rik
Summary
Predicted to enable lipid binding activity. Predicted to be involved in regulation of epidermal growth factor receptor signaling pathway; viral budding; and virus maturation. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including cytosol; early endosome; and nucleus. Predicted to be part of ESCRT I complex. Predicted to be active in late endosome. Is expressed in 2nd branchial arch and 3rd branchial pouch. Orthologous to human MVB12B (multivesicular body subunit 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 7.7), CNS E14 (RPKM 6.3) and 26 other tissues See more
Orthologs
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Genomic context

See Mvb12b in Genome Data Viewer
Location:
2 B; 2 22.51 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33619965..33777958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33729953..33887946, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene LIM homeobox transcription factor 1 beta Neighboring gene Riken cDNA C130021I20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:33544353-33544554 Neighboring gene RIKEN cDNA 9430024E24 gene Neighboring gene predicted gene, 52507 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:33672731-33672932 Neighboring gene predicted gene, 33856 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:33677308-33677491 Neighboring gene non-protein coding RNA, repressor of NFAT Neighboring gene VISTA enhancer mm716 Neighboring gene STARR-positive B cell enhancer mm9_chr2:33763748-33764049 Neighboring gene STARR-seq mESC enhancer starr_04250 Neighboring gene predicted gene, 39792 Neighboring gene STARR-positive B cell enhancer mm9_chr2:33789434-33789735 Neighboring gene predicted gene, 39793 Neighboring gene predicted gene 13403

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in viral budding ISO
Inferred from Sequence Orthology
more info
 
involved_in virus maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in virus maturation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
multivesicular body subunit 12B
Names
ESCRT-I complex subunit MVB12B
family with sequence similarity 125, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175184.4NP_780393.2  multivesicular body subunit 12B

    See identical proteins and their annotated locations for NP_780393.2

    Status: VALIDATED

    Source sequence(s)
    AL845360, BX649361
    Consensus CDS
    CCDS15946.1
    UniProtKB/Swiss-Prot
    A2ARF1, Q6KAU4, Q6PB42
    Related
    ENSMUSP00000048901.4, ENSMUST00000041555.10
    Conserved Domains (1) summary
    pfam10240
    Location:46297
    DUF2464; Protein of unknown function (DUF2464)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    33619965..33777958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498373.1XP_006498436.1  multivesicular body subunit 12B isoform X11

    Conserved Domains (1) summary
    pfam10240
    Location:47222
    DUF2464; Multivesicular body subunit 12
  2. XM_006498370.1XP_006498433.1  multivesicular body subunit 12B isoform X5

    Conserved Domains (1) summary
    pfam10240
    Location:47250
    DUF2464; Multivesicular body subunit 12
  3. XM_036162602.1XP_036018495.1  multivesicular body subunit 12B isoform X7

    UniProtKB/TrEMBL
    Q8C2W4
    Conserved Domains (1) summary
    pfam10240
    Location:17268
    DUF2464; Multivesicular body subunit 12
  4. XM_036162603.1XP_036018496.1  multivesicular body subunit 12B isoform X7

    UniProtKB/TrEMBL
    Q8C2W4
    Conserved Domains (1) summary
    pfam10240
    Location:17268
    DUF2464; Multivesicular body subunit 12
  5. XM_030252115.2XP_030107975.1  multivesicular body subunit 12B isoform X7

    UniProtKB/TrEMBL
    Q8C2W4
    Conserved Domains (1) summary
    pfam10240
    Location:17268
    DUF2464; Multivesicular body subunit 12
  6. XM_011239194.2XP_011237496.1  multivesicular body subunit 12B isoform X10

    Conserved Domains (1) summary
    pfam10240
    Location:47251
    DUF2464; Multivesicular body subunit 12
  7. XM_006498367.5XP_006498430.1  multivesicular body subunit 12B isoform X1

    Conserved Domains (1) summary
    pfam10240
    Location:47250
    DUF2464; Multivesicular body subunit 12
  8. XM_030252114.2XP_030107974.1  multivesicular body subunit 12B isoform X3

    Conserved Domains (1) summary
    pfam10240
    Location:18221
    DUF2464; Multivesicular body subunit 12
  9. XM_030252112.2XP_030107972.1  multivesicular body subunit 12B isoform X3

    Conserved Domains (1) summary
    pfam10240
    Location:18221
    DUF2464; Multivesicular body subunit 12
  10. XM_030252113.2XP_030107973.1  multivesicular body subunit 12B isoform X3

    Conserved Domains (1) summary
    pfam10240
    Location:18221
    DUF2464; Multivesicular body subunit 12
  11. XM_006498368.5XP_006498431.1  multivesicular body subunit 12B isoform X2

    Conserved Domains (1) summary
    pfam10240
    Location:39242
    DUF2464; Multivesicular body subunit 12
  12. XM_006498372.1XP_006498435.1  multivesicular body subunit 12B isoform X9

    Conserved Domains (1) summary
    pfam10240
    Location:47251
    DUF2464; Multivesicular body subunit 12
  13. XM_006498371.5XP_006498434.1  multivesicular body subunit 12B isoform X6

    Conserved Domains (1) summary
    pfam10240
    Location:18222
    DUF2464; Multivesicular body subunit 12
  14. XM_006498369.4XP_006498432.1  multivesicular body subunit 12B isoform X4

    Conserved Domains (1) summary
    pfam10240
    Location:47251
    DUF2464; Multivesicular body subunit 12
  15. XM_036162605.1XP_036018498.1  multivesicular body subunit 12B isoform X8

    Conserved Domains (1) summary
    pfam10240
    Location:46251
    DUF2464; Multivesicular body subunit 12