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Taf4b TATA-box binding protein associated factor 4b [ Mus musculus (house mouse) ]

Gene ID: 72504, updated on 21-Apr-2024

Summary

Official Symbol
Taf4bprovided by MGI
Official Full Name
TATA-box binding protein associated factor 4bprovided by MGI
Primary source
MGI:MGI:2152345
See related
Ensembl:ENSMUSG00000054321 AllianceGenome:MGI:2152345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
105kDa; Taf2c2; TAFII105; TAFII-105; 2610524B04Rik; 4932409F03Rik
Summary
Predicted to enable DNA binding activity and NF-kappaB binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of stem cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Is expressed in genitourinary system and tail. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Orthologous to human TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 3.7), testis adult (RPKM 2.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
18 A1; 18 8.28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (14916302..15035160)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (14783201..14960424)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene SS18, subunit of BAF chromatin remodeling complex Neighboring gene predicted gene, 24924 Neighboring gene STARR-seq mESC enhancer starr_43875 Neighboring gene STARR-seq mESC enhancer starr_43877 Neighboring gene proteasome subunit alpha 8 Neighboring gene STARR-positive B cell enhancer ABC_E1951 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_43878 Neighboring gene RIKEN cDNA 4930543D07 gene Neighboring gene SUMO/sentrin specific peptidase 5 pseudogene Neighboring gene predicted gene, 54035

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 4B
Names
TAF(II)105
TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105 kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
transcription initiation factor TFIID 105 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100449.2NP_001093919.1  transcription initiation factor TFIID subunit 4B isoform 1

    See identical proteins and their annotated locations for NP_001093919.1

    Status: VALIDATED

    Source sequence(s)
    AC102692, AC125091, AC133172
    Consensus CDS
    CCDS50227.1
    UniProtKB/Swiss-Prot
    G5E8Z2
    UniProtKB/TrEMBL
    A0A3B2W725
    Related
    ENSMUSP00000126909.2, ENSMUST00000169862.2
    Conserved Domains (2) summary
    pfam05236
    Location:610850
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:257343
    TAFH; NHR1 homology to TAF
  2. NM_001369357.1NP_001356286.1  transcription initiation factor TFIID subunit 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102692, AC125091, AC133172
    Consensus CDS
    CCDS89195.1
    UniProtKB/Swiss-Prot
    G5E8Z2
    UniProtKB/TrEMBL
    A0A3Q4EGS4
    Related
    ENSMUSP00000157354.2, ENSMUST00000234789.2
    Conserved Domains (3) summary
    PRK14950
    Location:291
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam05236
    Location:605845
    TAF4; Transcription initiation factor TFIID component TAF4 family
    pfam07531
    Location:257343
    TAFH; NHR1 homology to TAF
  3. NM_001369358.1NP_001356287.1  transcription initiation factor TFIID subunit 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102692, AC125091, AC133172
    UniProtKB/Swiss-Prot
    G5E8Z2
    Conserved Domains (4) summary
    COG5665
    Location:137318
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    PRK14950
    Location:291
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam05236
    Location:564804
    TAF4; Transcription initiation factor TFIID component TAF4 family
    cl02658
    Location:253302
    TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    14916302..15035160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)