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Lypd3 Ly6/Plaur domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 72434, updated on 12-May-2024

Summary

Official Symbol
Lypd3provided by MGI
Official Full Name
Ly6/Plaur domain containing 3provided by MGI
Primary source
MGI:MGI:1919684
See related
Ensembl:ENSMUSG00000057454 AllianceGenome:MGI:1919684
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C4.4a; 2310061G07Rik
Summary
Predicted to enable laminin binding activity. Predicted to act upstream of or within cell-matrix adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including epithelium; foregut; sensory organ; skin; and thymus. Orthologous to human LYPD3 (LY6/PLAUR domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 103.6), bladder adult (RPKM 19.2) and 2 other tissues See more
Orthologs
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Genomic context

See Lypd3 in Genome Data Viewer
Location:
7 A3; 7 11.95 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24335995..24340543)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24636570..24641118)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 575 Neighboring gene ethylmalonic encephalopathy 1 Neighboring gene STARR-seq mESC enhancer starr_18271 Neighboring gene STARR-positive B cell enhancer ABC_E4903 Neighboring gene pleckstrin homology like domain, family B, member 3 Neighboring gene predicted gene, 26550 Neighboring gene predicted gene 4598 Neighboring gene testis expressed gene 101

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables laminin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 3
Names
GPI-anchored metastasis-associated protein C4.4A homolog
GPI-anchored metastasis-associated protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133743.1NP_598504.1  ly6/PLAUR domain-containing protein 3 precursor

    See identical proteins and their annotated locations for NP_598504.1

    Status: PROVISIONAL

    Source sequence(s)
    BC016549
    Consensus CDS
    CCDS20958.1
    UniProtKB/Swiss-Prot
    Q91YK8
    Related
    ENSMUSP00000079543.5, ENSMUST00000080718.6
    Conserved Domains (2) summary
    cd00117
    Location:33118
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    pfam00021
    Location:142224
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24335995..24340543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)