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Sgo1 shugoshin 1 [ Mus musculus (house mouse) ]

Gene ID: 72415, updated on 8-Dec-2022

Summary

Official Symbol
Sgo1provided by MGI
Official Full Name
shugoshin 1provided by MGI
Primary source
MGI:MGI:1919665
See related
Ensembl:ENSMUSG00000023940 AllianceGenome:MGI:1919665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgol1; 3300001M08Rik
Summary
Predicted to enable kinase binding activity. Acts upstream of or within centriole-centriole cohesion. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 10.7), CNS E11.5 (RPKM 8.5) and 9 other tissues See more
Orthologs
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Genomic context

See Sgo1 in Genome Data Viewer
Location:
17; 17 C
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (53981814..53996432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (53674786..53691331, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene K(lysine) acetyltransferase 2B Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene predicted gene, 31532 Neighboring gene RAB5A, member RAS oncogene family, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC113769

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
shugoshin 1
Names
shugoshin 1A protein
shugoshin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028232.2NP_082508.1  shugoshin 1

    See identical proteins and their annotated locations for NP_082508.1

    Status: VALIDATED

    Source sequence(s)
    AK014357, AK049517, BY394301, CR522550
    Consensus CDS
    CCDS28881.1
    UniProtKB/Swiss-Prot
    Q8BKW2, Q9CXH7
    Related
    ENSMUSP00000024736.8, ENSMUST00000024736.14
    Conserved Domains (2) summary
    pfam07557
    Location:465486
    Shugoshin_C; Shugoshin C-terminus
    pfam07558
    Location:2266
    Shugoshin_N; Shugoshin N-terminal coiled-coil region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    53981814..53996432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246642.4XP_011244944.1  shugoshin 1 isoform X1

    See identical proteins and their annotated locations for XP_011244944.1

    UniProtKB/Swiss-Prot
    Q8BKW2, Q9CXH7
    Conserved Domains (2) summary
    pfam07557
    Location:465486
    Shugoshin_C; Shugoshin C-terminus
    pfam07558
    Location:2266
    Shugoshin_N; Shugoshin N-terminal coiled-coil region