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Wdr44 WD repeat domain 44 [ Mus musculus (house mouse) ]

Gene ID: 72404, updated on 26-Sep-2022

Summary

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Official Symbol
Wdr44provided by MGI
Official Full Name
WD repeat domain 44provided by MGI
Primary source
MGI:MGI:1919654
See related
Ensembl:ENSMUSG00000036769 AllianceGenome:MGI:1919654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPH11; RAB11BP; 2610034K17Rik
Summary
This gene encodes a protein containing multiple WD repeats. The encoded protein may play a role in vesicle trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Ubiquitous expression in bladder adult (RPKM 2.9), CNS E18 (RPKM 2.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wdr44 in Genome Data Viewer
Location:
X; X A2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (23559231..23672265)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (23692402..23806026)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1395 Neighboring gene kelch-like 13 Neighboring gene cyclin-dependent kinase 2 interacting protein pseudogene Neighboring gene testis derived transcript pseudogene Neighboring gene testin LIM domain protein like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. Mammoto A, et al. J Biol Chem, 2000 May 5. PMID 10747849
  2. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. Baron Y, et al. BMC Biol, 2014 May 29. PMID 24885147, Free PMC Article
  3. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • 9130203L06, DKFZp686L20145

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 44
Names
rabphilin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305675.1 → NP_001292604.1  WD repeat-containing protein 44

    See identical proteins and their annotated locations for NP_001292604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BB619844, BC068151
    Consensus CDS
    CCDS40892.1
    UniProtKB/Swiss-Prot
    Q6NVE8, Q8BTS1
    Related
    ENSMUSP00000099193.3, ENSMUST00000101670.3
    Conserved Domains (2) summary
    sd00039
    Location:516 → 607
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:512 → 859
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_175180.3 → NP_780389.2  WD repeat-containing protein 44

    See identical proteins and their annotated locations for NP_780389.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BB619844, BC068151
    Consensus CDS
    CCDS40892.1
    UniProtKB/Swiss-Prot
    Q6NVE8, Q8BTS1
    Related
    ENSMUSP00000044616.7, ENSMUST00000035766.13
    Conserved Domains (2) summary
    sd00039
    Location:516 → 607
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:512 → 859
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    23559231..23672265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527700.5 → XP_006527763.1  WD repeat-containing protein 44 isoform X1

    See identical proteins and their annotated locations for XP_006527763.1

    UniProtKB/Swiss-Prot
    Q6NVE8, Q8BTS1
    Conserved Domains (2) summary
    sd00039
    Location:516 → 607
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:512 → 859
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NVE8.1 GenPept UniProtKB/Swiss-Prot:Q6NVE8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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