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mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 724006, updated on 9-Sep-2025
Official Symbol
mgat5provided by ZNC
Official Full Name
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060616-238
See related
Ensembl:ENSDARG00000071506 AllianceGenome:ZFIN:ZDB-GENE-060616-238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mgat5a; zgc:136939; si:dkeyp-4h4.2
Summary
Predicted to enable alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within neuromast hair cell differentiation involved in neuromast regeneration. Predicted to be located in Golgi membrane and extracellular region. Predicted to be active in Golgi apparatus. Is expressed in gut and nervous system. Orthologous to human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See mgat5 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 22 NC_133197.1 (11631477..11750385)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 22 NC_007133.7 (11972820..12091448)

Chromosome 22 - NC_133197.1Genomic Context describing neighboring genes Neighboring gene muscle RAS oncogene homolog b Neighboring gene parathyroid hormone 2 receptor b Neighboring gene transmembrane protein 163b Neighboring gene uncharacterized LOC137488913 Neighboring gene cyclin T2b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish. Pei W, et al. Cell Regen, 2016. PMID 27795824, Free PMC Article
  2. Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. Pei W, et al. NPJ Regen Med, 2018. PMID 29872546, Free PMC Article
  3. O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder. Matheny-Rabun C, et al. Cell Rep, 2024 Nov 26. PMID 39561044, Free PMC Article
  4. In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Clark KJ, et al. Nat Methods, 2011 Jun. PMID 21552255, Free PMC Article
  5. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuromast hair cell differentiation involved in neuromast regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein N-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
Names
mannoside acetylglucosaminyltransferase 5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
NP_001038776.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045311.1 → NP_001038776.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

    See identical proteins and their annotated locations for NP_001038776.1

    Status: PROVISIONAL

    Source sequence(s)
    BC117664
    UniProtKB/TrEMBL
    A0A8M1NAP4, Q1ECU6
    Related
    ENSDARP00000096566.4, ENSDART00000105788.5
    Conserved Domains (2) summary
    pfam15024
    Location:173 → 727
    Glyco_transf_18; Glycosyltransferase family 18
    pfam15027
    Location:3 → 139
    DUF4525; Domain of unknown function (DUF4525)

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133197.1 Reference GRCz12tu Primary Assembly

    Range
    11631477..11750385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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