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H2AC19 H2A clustered histone 19 [ Homo sapiens (human) ]

Gene ID: 723790, updated on 5-Aug-2022

Summary

Official Symbol
H2AC19provided by HGNC
Official Full Name
H2A clustered histone 19provided by HGNC
Primary source
HGNC:HGNC:29668
See related
Ensembl:ENSG00000288859 AllianceGenome:HGNC:29668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2A/R; H2AC18; HIST2H2AA4
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2AC19 in Genome Data Viewer
Location:
1q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149851061..149851594)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148975201..148975734)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149822628..149823161)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 19, pseudogene Neighboring gene H4 clustered histone 15 Neighboring gene H2B clustered histone 20, pseudogene Neighboring gene H3 clustered histone 15 Neighboring gene H2B clustered histone 21

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2A type 2-A
Names
H2A-clustered histone 18
histone 2, H2aa4
histone H2A/r
histone cluster 2 H2A family member a4
histone cluster 2, H2aa4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040874.1NP_001035807.1  histone H2A type 2-A

    See identical proteins and their annotated locations for NP_001035807.1

    Status: REVIEWED

    Source sequence(s)
    AC239868
    Consensus CDS
    CCDS30849.1
    UniProtKB/Swiss-Prot
    P20670, Q6FI13
    Related
    ENSP00000475814.1, ENST00000607355.3
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149851061..149851594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    148975201..148975734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)